Sigirr
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Official Full Name
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain -
Overview
Single Ig IL-1-related receptor is a protein that in humans is encoded by the SIGIRR gene. -
Synonyms
SIGIRR;single immunoglobulin and toll-interleukin 1 receptor (TIR) domain;single Ig IL-1-related receptor;single immunoglobulin domain IL1R1 related;TIR8;Single immunoglobulin domain containing IL1R related protein;Toll/interleukin 1 receptor 8;Ig IL1 related receptor;MGC110992;SIGIR_HUMAN;Single Ig IL 1 related receptor;Single Ig IL-1R-related molecule;Single Ig IL1R Related Molecule;Single immunoglobulin and toll interleukin 1 receptor (TIR) domain;Single immunoglobulin and toll interleukin 1 receptor domain;Single immunoglobulin domain-containing IL1R-related protein;TIR 8;Toll/interleukin-1 receptor 8;OTTHUMP00000229641;OTTHUMP00000229642;OTTHUMP00000229643;OTTHUMP00000229644;OTTHUMP00000229645;single immunoglobulin
Recombinant Proteins
- Human
- Chicken
- Mouse
- Rat
- Zebrafish
- HEK293
- Mammalian cells
- E.coli
- Human Cell
- Mammalian Cell
- HEK293T
- Yeast
- His
- Non
- Fc
- His&Fc
- His&Fc&Avi
- Myc&DDK
- His&GST
- His&SUMO
Involved Pathway
Sigirr involved in several pathways and played different roles in them. We selected most pathways Sigirr participated on our site, such as Activated TLR4 signalling,Immune System,Innate Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with Sigirr were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Activated TLR4 signalling | NOD1,PELI3,DUSP6,DUSP7,ATF2,MAP3K8,DUSP4,TNIP2,UBE2V1,RIPK3 |
| Toll Like Receptor 4 (TLR4) Cascade | CD180,LY86 |
| Innate Immune System | CLEC4D,ABI1B,CLEC5A,DEFA3,LAT2,HBL3,S100B,ACTR2B,CTS7,FCN3 |
| Immune System | RNF41,LILRB4,CD200R1,CTSE,CTSLL,ISG20,LGALS3,ARIH1L,ASB4,KIF26A |
| MyD88:Mal cascade initiated on plasma membrane | IRAK3 |
Protein Function
Sigirr has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Sigirr itself. We selected most functions Sigirr had, and list some proteins which have the same functions with Sigirr. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | LDLRAD1,PRPSAP1,HIST1H1A,C19orf60,PTI,LEF1,PTPRD,SERPING1,THEG,BTF3L4 |
Interacting Protein
Sigirr has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Sigirr here. Most of them are supplied by our site. Hope this information will be useful for your research of Sigirr.
RPN1;ENO2;yhdI
Resources
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References
- Bulau, AM; Nold, MF; et al. Role of caspase-1 in nuclear translocation of IL-37, release of the cytokine, and IL-37 inhibition of innate immune responses. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111:2650-2655(2014).
- Trevisi, E; Amadori, M; et al. Evaluation of innate immune responses in bovine forestomachs. RESEARCH IN VETERINARY SCIENCE 96:69-78(2014).
