SUMO2
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Official Full Name
SMT3 suppressor of mif two 3 homolog 2 -
Overview
This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last two amino acids of the carboxy-terminus have been cleaved off. Numerous pseudogenes have been reported for this gene. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. -
Synonyms
SUMO2;SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae);SMT3 (suppressor of mif two 3, yeast) homolog 2 , SMT3 suppressor of mif two 3 homolog 2 (yeast) , SMT3H2;small ubiquitin-related modifier 2;SMT3B;sentrin 2;SMT3 homolog 2;ubiquitin-like
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rhesus macaque
- Rat
- Cynomolgus
- E.coli
- Mammalian Cell
- E. coli
- HEK293T
- HEK293
- His
- Non
- GST
- His&Strep
- Myc&DDK
- His&Fc&Avi
Involved Pathway
SUMO2 involved in several pathways and played different roles in them. We selected most pathways SUMO2 participated on our site, such as RNA transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with SUMO2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RNA transport | KPNB1,SUMO1,EIF4BA,CYFIP2,RPP40,EEF1A2,CASC3,UPF1,NUP188,THOC7 |
Protein Function
SUMO2 has several biochemical functions, for example, poly(A) RNA binding,protein binding,protein tag. Some of the functions are cooperated with other proteins, some of the functions could acted by SUMO2 itself. We selected most functions SUMO2 had, and list some proteins which have the same functions with SUMO2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | CROP,Cstb,SOSTDC1B,WDR6,RBM38,KPNB1,FXR1,DDX10,MARK2,FAM46A |
| protein tag | SUMO4,SUMO3,RNF41,SUMO3A,SUMO2B,UBL5,NFATC2IP,ISG15,SUMO1,SUMO3B |
| ubiquitin protein ligase binding | KDM4A,FBXW7,FLJ11011L,TUBB,RELA,TNFRSF14,CUL5A,DTX1,TRIM28,CCDC50 |
| protein binding | TPR,PRKCE,CXCR2,ASB2,IL-8,STX18,WRNIP1,MYBPC1,C2orf63,ALOX12 |
Interacting Protein
SUMO2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SUMO2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SUMO2.
CHD3;PELP1;USPL1;uspl1;HOMEZ;SENP2;USP25
SUMO2 Related Signal Pathway
Resources
Research Area
Ubiquitin-like Modifiers (UBLs) and RegulatorsPost-translational Modification of NFkB/IkB
Related Services
Related Products
References
- Collaud, S; Tischler, V; et al. Lung neuroendocrine tumors: correlation of ubiquitinylation and sumoylation with nucleo-cytosolic partitioning of PTEN. BMC CANCER 15:-(2015).
- Bund, T; Spoden, GA; et al. An L2 SUMO interacting motif is important for PML localization and infection of human papillomavirus type 16. CELLULAR MICROBIOLOGY 16:1179-1200(2014).
