SULT2A1
-
Official Full Name
sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 -
Overview
Dehydroepiandrosterone sulfate or DHEA sulfate is a metabolite of dehydroepiandrosterone (DHEA) produced by the addition of a sulfate group, catalyzed by the sulfotransferase enzymes SULT1A1 and SULT1E1, which also produce estrone sulfate from estrone. DHEA sulfate can also be back-converted to DHEA through the action of steroid sulfatase.In the zona reticularis layer of the adrenal cortex, DHEA-sulfate is generated by SULT2A1. This layer of the adrenal cortex is thought to be the primary source of serum DHEA-sulfate. DHEA sulfate levels decline as a person ages as the reticularis layer diminishes in size. -
Synonyms
Alcohol/hydroxysteroid sulfotransferase;Bile salt sulfotranasferase 2A1;Bile salt sulfotransferase;Dehydroepiandrosterone sulfotransferase;DHEA ST;DHEA-ST;DHEAS;EC 2.8.2.14;HST;hSTa;Hydroxysteroid Sulfotransferase;ST2;ST2A1;ST2A1_HUMAN;ST2A3;STD Sulfotransferase 2A1;Sulfotransferase family cytosolic 2A dehydroepiandrosterone (DHEA) preferring member 1;Sult2a1
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Mammalian Cell
- Human
- HEK293
- Mouse
- HEK293T
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
SULT2A1 involved in several pathways and played different roles in them. We selected most pathways SULT2A1 participated on our site, such as Metabolism of xenobiotics by cytochrome P,Bile secretion,Chemical carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SULT2A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Bile secretion | AQP9,SLC4A4,ATP1A3,SLCO1A6,ADCY3,CFTR,ATP1B4,SLC9A3,ABCC3,GNAS |
| Metabolism of xenobiotics by cytochrome P | EPHX1,ADH1,GSTAL,UGT1A3,UGT1AB,UGT2B15,CBR1L,AKR7A5,ALDH3B2,GSTT2B |
| Chemical carcinogenesis | UGT1A6B,GSTT2,GSTK1,CYP2A6,MGST1,CYP2C37,CYP2E1,GSTM1,SULT1A3,GSTO2 |
Protein Function
SULT2A1 has several biochemical functions, for example, bile-salt sulfotransferase activity,protein binding,sulfotransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SULT2A1 itself. We selected most functions SULT2A1 had, and list some proteins which have the same functions with SULT2A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| sulfotransferase activity | SULT1D1,CHST3B,HS3ST3B1B,CHST4,HS6ST3B,CHST3A,SULT3ST3,GAL3ST1,CHST2A,UST |
| protein binding | PLAT,TRIM69,PCBD1,HMOX2,CARS,ZNF398,CD81,HAPLN2,MAGEA8,THRAA |
Interacting Protein
SULT2A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SULT2A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SULT2A1.
SULT1B1;STAT3;PRDX4;STK3;TMX1
Resources
Related Services
Related Products
References
- Fujimura, H; Murakami, N; et al. The suitability of rat hepatoma cell line H4IIE for evaluating the potentials of compounds to induce CYP3A23 expression. EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY 64:527-533(2012).
- Gong, JC; Gan, JP; et al. Identification of the Oxidative and Conjugative Enzymes Involved in the Biotransformation of Brivanib. DRUG METABOLISM AND DISPOSITION 40:219-226(2012).
