STAT2
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Official Full Name
signal transducer and activator of transcription 2, 113kDa -
Overview
STAT proteins (Signal Transduction and Activators of Transcription) are latent cytoplasmic transcription factors that have the dual function of signal transduction and activation of transcription. STATs are activated by tyrosine phosphorylation in response to different ligands, after which they translocate to the cell nucleus. STATs are a part of the JAK-STAT signaling pathway – a major pathway of the immune system. All cytokines transduce critical signals through this pathway. Stat2 (113 kDa), originally purified from the nuclei of alpha-interferon-treated cells,Is critical to the transcriptional responses induced by type I interferons,ifN-alpha/beta. Knockout mice with a targeted disruption of Stat2 have higher susceptibility to viral infection and altered responses to type I interferons. Stat2 is rapidly activated by phosphorylation at Tyr690 in response to stimulation by ifN-alpha/beta via assocations with receptor-bound Jak kinases. -
Synonyms
STAT2;signal transducer and activator of transcription 2, 113kDa;signal transducer and activator of transcription 2, 113kD;signal transducer and activator of transcription 2;STAT113;interferon alpha induced transcriptional activator;P113;ISGF-3;MGC59816
Recombinant Proteins
- Human
- Mouse
- Rat
- Rhesus macaque
- Zebrafish
- E.coli
- Sf9 Cells
- Insect Cells
- Mammalian Cells
- Sf21 Cells
- HEK293
- Human Cells
- GST
- His
- His&T7
- Non
- His&MBP
- His&Fc&Avi
- Myc&DDK
Involved Pathway
STAT2 involved in several pathways and played different roles in them. We selected most pathways STAT2 participated on our site, such as Chemokine signaling pathway,Osteoclast differentiation,Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with STAT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chemokine signaling pathway | RAF1,CCL5,Ccl21a,GNG8,FOXO3,STAT5B,CCL21,CCL7,CCL4,GRB2 |
| Hepatitis C | TRAF2,CLDN17,PPP2R1B,PIK3CG,TRP53,IFNA4,CLDN16,MAVS,PPARA,IKBKB |
| Influenza A | NFKB1,TNFSF10,GSK3B,ICAM1,IFNA17,ADAR,PRKCB,PRSS2,LOC100686744,HLA-DRB5 |
| Osteoclast differentiation | SOCS1,IFNGR2,cgr2b,TRAF2,IL1R1,FCGR2C,MAPK1,NFATC2,TYROBP,FOSB |
| Measles | OAS1B,IL4,CD209,OAS2,IL2RG,TACR1,HSPA2,TLR7,cgr2b,TLR4 |
| Jak-STAT signaling pathway | IL6ST,AKT2L,IL20,AOX3L1,LEPB,RNF207B,PIK3R3,PIAS2,BCL2A,IL21R.1 |
| Hepatitis B | TLR2,STAT5B,Casp3,BIRC5,PIK3R1,AKT2,HBXIP,STAT6,IKBKB,RAF1 |
| Herpes simplex infection | IL15,TBPL2,Hc,MAPK8A,OAS1A,CASP3A,SRSF4,NFKBIA,OAS3,NXF1 |
Protein Function
STAT2 has several biochemical functions, for example, DNA binding,identical protein binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by STAT2 itself. We selected most functions STAT2 had, and list some proteins which have the same functions with STAT2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | NEK9,MLST8,ARHGAP5,RAB26,TRDN,HIST1H3C,TSSK2,MED30,ALCAM,MED16 |
| signal transducer activity | OLFR1002,DRD4-RS,Fzd4,TAS2R200.1,GNA11B,MTNR1BA,STAT1A,TAAR13C,TAS2R144,OLFR10 |
| DNA binding | ZNF385A,SOX6,SMTNL,BEND5,HIST1H2B7,Alb,FOXC1B,VDR,DDIT3,TOX4 |
| transcription factor activity, sequence-specific DNA binding | SP1,ZKSCAN4,ATF3,ZIC1,Aff1,GABPB1,HOXC4,TFEB,ZNF16,TBX2B |
| identical protein binding | SFRP1,GOT2B,DYNLT1B,CLDN1,GRIN3A,DVL1,FNBP1,TNPO3,SHMT2,ALCAMA |
Interacting Protein
STAT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STAT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of STAT2.
STAT1;IFNAR1;IRF9
STAT2 Related Signal Pathway
Resources
Research Area
Apoptosis Transcription Factors and RegulatorsNegative Regulators of the Jak/STAT Pathway
STAT
IL-10 Signaling Related Molecules
IL-6 Signaling Related Molecules
Related Services
Related Products
References
