SSX1
-
Official Full Name
synovial sarcoma, X breakpoint 1 -
Overview
The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are probably responsible for transforming activity. -
Synonyms
SSX1;synovial sarcoma, X breakpoint 1;protein SSX1;cancer/testis antigen family 5;member 1;CT5.1;X breakpoint 1;Cancer/testis antigen 5.1;Cancer/testis antigen family 5 member 1;MGC150425;MGC5162;sarcoma, synovial, X chromosome related 1;SSRC;SSX1_HUMAN;Synovial sarcoma;cancer/testis antigen family 5, member 1;sarcoma, synovial, X-chromosome-related 1
Recombinant Proteins
- Human
- Wheat Germ
- E.coli
- HEK293
- Mammalian cells
- In Vitro Cell Free System
- Non
- His
- Myc&DDK
- Flag
- His&Fc&Avi
- N-His-SUMO
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SSX1-30141TH | Recombinant Human SSX1 | Wheat Germ | Human | Non | 188 amino acids |
|
| SSX1-31171TH | Recombinant Human SSX1 | Wheat Germ | Human | Non | 100 amino acids |
|
| SSX1-7541H | Recombinant Human SSX1, His-tagged | E.coli | Human | His | 1-188aa |
|
| SSX1-1450HCL | Recombinant Human SSX1 293 Cell Lysate | HEK293 | Human | Non |
|
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| SSX1-021H | Recombinant Human SSX1 Protein, MYC/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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| SSX1-2040HFL | Recombinant Full Length Human SSX1 Protein, C-Flag-tagged | Mammalian cells | Human | Flag | Full L. |
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| SSX1-2108H | Recombinant Human SSX1 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| SSX1-2108H-B | Recombinant Human SSX1 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| SSX1-499HF | Recombinant Full Length Human SSX1 Protein | In Vitro Cell Free System | Human | Full L. 188 amino acids |
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| SSX1-755H | Recombinant Human SSX1 protein, His-SUMO-tagged | E.coli | Human | N-His-SUMO | 1-188aa |
|
Involved Pathway
SSX1 involved in several pathways and played different roles in them. We selected most pathways SSX1 participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with SSX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transcriptional misregulation in cancer | HIST1H3G,WHSC1,ETV5,CEBPE,IGFBP3,IL1R2,RXRA,REL,DEFA3,ETV6 |
Protein Function
SSX1 has several biochemical functions, for example, nucleic acid binding,protein binding,transcription corepressor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SSX1 itself. We selected most functions SSX1 had, and list some proteins which have the same functions with SSX1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription corepressor activity | NEUROD2,TBL1Y,PROX1,TBL1XR1A,DR1,NR2F2,CBX4,CBFA2T2,GMNN,TFAP2B |
| nucleic acid binding | NELFE,ZFP628,ZFP13,PNMA3,ZNF843,ZFP91,SRSF9,NPM1B,ZFP11,KRBOX4 |
| protein binding | CPEB3,ZNF544,CDK8,WFDC9,SPI1,GSTP1,CCDC88A,KLRB1B,COPRS,LGALS2 |
Interacting Protein
SSX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SSX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SSX1.
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References
- He, R; Patel, RM; et al. Immunostaining for SYT protein discriminates synovial sarcoma from other soft tissue tumors: analysis of 146 cases. MODERN PATHOLOGY 20:522-528(2007).
- Atanackovic, D; Arfsten, J; et al. Cancer-testis antigens are commonly expressed in multiple myeloma and induce systemic immunity following allogeneic stem cell transplantation. BLOOD 109:1103-1112(2007).
