SOX2
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Official Full Name
SRY (sex determining region Y)-box 2 -
Overview
This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq, Jul 2008] -
Synonyms
SOX2;SRY (sex determining region Y)-box 2;ANOP3;MCOPS3;transcription factor SOX-2;transcription factor SOX2;SRY-related HMG-box gene 2
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rhesus macaque
- Chicken
- E.coli
- Mammalian Cell
- HEK293
- Mammalian cells
- HEK293T
- Mamanlian cells
- Non
- His
- Myc&DDK
- Flag
- His&Fc&Avi
- N-MBP & C-His
- GST
- His&SUMO
Involved Pathway
SOX2 involved in several pathways and played different roles in them. We selected most pathways SOX2 participated on our site, such as Hippo signaling pathway,Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with SOX2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signaling pathways regulating pluripotency of stem cells | GSK3B,ZIC3,APC,SMAD2,AKT1,INHBE,INHBC,FGFR1,SMAD3,LIFR |
| Hippo signaling pathway | FZD10,WNT8A,JUB,TEAD4,ID1,LLGL1,AXIN2,WNT7B,LATS2,TEAD2 |
Protein Function
SOX2 has several biochemical functions, for example, DNA binding,miRNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SOX2 itself. We selected most functions SOX2 had, and list some proteins which have the same functions with SOX2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor activity, sequence-specific DNA binding | ZNF792,HEYL,TCEAL1,ZNF571,AHRRB,SIX4,FBXW7,VAX2,SOX1,FOXL1 |
| protein binding | UBR2,PCSK2,FLI1,TRIAP1,ZNF346,UBA3,RTN2,FAM212A,PFDN2,DNA2 |
| transcription regulatory region sequence-specific DNA binding | NR5A1B,ARNTL1A,MKL1,SUV39H1,SOX12,FOXJ1,CREB3L3,NONO,PER2,SOX11 |
| transcription regulatory region DNA binding | DHX36,SERPINB1A,IKZF4,RELA,SOX7,CREB3L2,TBL1X,IKZF3,SFPQ,FOXC2 |
| miRNA binding | LIN28A,AGO1,AGO3,DICER1,AGO2,POU5F1,RBM4,MEF2C,TRIM71,TARBP2 |
| sequence-specific DNA binding | IRX4A,NFIL3-5,CREB3L3L,ELF2B,HOXD12,HIC1,ZGPAT,POU5F1,PPARAB,HSF4 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | HOXA7,FIGLA,CEBPA,EBF3A,DLX3,NR1H4,STK16,EBF4,FOSB,MAFB |
| DNA binding | HMG20B,E2F4,LHX8,NEUROD6B,PQBP1,Rhox5,ZFP523,MAP3K7,TEAD2,DMBX1 |
Interacting Protein
SOX2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SOX2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SOX2.
SUMO1;PRKCI;POU5F1;SALL2;CASP8;hhat_human_gene;gli2_human_gene;jag1_human_gene;gli3_human_gene;mycn_human_gene;necd_human_gene
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References
- Tyagi, D; Perez, JB; et al. Detection of embryonic stem cell lysate biomarkers by surface plasmon resonance with reduced nonspecific adsorption. ANALYTICAL BIOCHEMISTRY 471:29-37(2015).
- Ginisty, A; Gely-Pernot, A; et al. Evidence for a Subventricular Zone Neural Stem Cell Phagocytic Activity Stimulated by the Vitamin K-Dependent Factor Protein S. STEM CELLS 33:515-525(2015).
