SMPD1
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Official Full Name
sphingomyelin phosphodiesterase 1, acid lysosomal -
Overview
Sphingomyelinases (SMases) catalyze the hydrolysis of sphingomyelin to produce ceramide and phosphocholine. Ceramide is an important bioactive lipid triggering signal transduction involved in cell proliferation, apoptosis and differentiation. A number of -
Synonyms
SMPD1;sphingomyelin phosphodiesterase 1, acid lysosomal;sphingomyelin phosphodiesterase;acid sphingomyelinase;ASM;NPD;ASMASE
Recombinant Proteins
- Human
- Mouse
- Insect Cell
- Insect Cells
- CHO
- HEK293
- Wheat Germ
- E.coli
- HEK293T
- Mammalian cells
- His
- Non
- His&T7
- His&Fc&Avi
- Myc&DDK
- His&SUMO
- Flag
Involved Pathway
SMPD1 involved in several pathways and played different roles in them. We selected most pathways SMPD1 participated on our site, such as Sphingolipid metabolism,Metabolic pathways,Sphingolipid signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMPD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Lysosome | GM2A,CD63,AP3D1,LAPTM5,AP4B1,PPT1,ARSA,ATP6V0C,ENTPD4,HYAL1 |
| Sphingolipid metabolism | SGPP2,NEU1,ARSK,SPHK2,ARSD,NEU3.5,SMPD2,SGPL1,CERK,SPTLC2A |
| Sphingolipid signaling pathway | PPP2R3C,GAB2,SGMS1,BID,PPP2R2B,DEGS2,PLCB3,GNAQ,S1PR4,RELA |
| Metabolic pathways | NME2B.2,FAM213B,HEXB,COX6A1,AK2,POLR1D,SAT1,NAT2,CYP27A1,EHHADH |
Protein Function
SMPD1 has several biochemical functions, for example, hydrolase activity, acting on glycosyl bonds,protein binding,sphingomyelin phosphodiesterase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SMPD1 itself. We selected most functions SMPD1 had, and list some proteins which have the same functions with SMPD1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| hydrolase activity, acting on glycosyl bonds | SMPDL3A,GALCA,MAN1A,Chil3,LYZ2,MUTYH,SPACA5,NEIL1,MOGS,Art2b |
| sphingomyelin phosphodiesterase activity | SMPDL3A,SMPD2A,SMPD3,SMPD2,ENPP7,SMPD4,SMPD5,SMPDL3B |
| protein binding | PSMA3,MTA2,IFIT3,TEKT4,STIP1,FOXC2,LTBR,RNF111,BRCC3,SCAMP2 |
Interacting Protein
SMPD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMPD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMPD1.
CASP7;CASP8;ANXA4;ANXA7;NR1H2;DUSP23;TNFRSF1A
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