SLX1B
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Official Full Name
SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae) -
Overview
This gene encodes a protein that is an important regulator of genome stability. The protein represents the catalytic subunit of the SLX1-SLX4 structure-specific endonuclease, which can resolve DNA secondary structures that are formed during repair and recombination processes. Two identical copies of this gene are located on the p arm of chromosome 16 due to a segmental duplication; this record represents the more telomeric copy. Alternative splicing results in multiple transcript variants. Read-through transcription also occurs between this gene and the downstream SULT1A4 (sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4) gene. -
Synonyms
SLX1B;SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae);GIY YIG domain containing 2 , GIYD2;structure-specific endonuclease subunit SLX1;MGC5178;FLJ23439;GIY YIG domain containing 2;GIYD 2;MGC2532;GIY-YIG domain-containing protein 1;GIYD1;GIYD2;SLX1A
Recombinant Proteins
- Rhesus macaque
- Rat
- Human
- Mammalian Cell
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- His&Fc&Avi
- GST
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SLX1B-4328R | Recombinant Rhesus monkey SLX1B Protein, His-tagged | Mammalian Cell | Rhesus macaque | His |
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| SLX1B-5606R | Recombinant Rat SLX1B Protein | Mammalian Cell | Rat | His |
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| SLX1B-5924HCL | Recombinant Human GIYD2 293 Cell Lysate | HEK293 | Human | Non |
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| SLX1B-4144R | Recombinant Rhesus Macaque SLX1B Protein, His (Fc)-Avi-tagged | HEK293 | Rhesus macaque | His&Fc&Avi |
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| SLX1B-4144R-B | Recombinant Rhesus Macaque SLX1B Protein Pre-coupled Magnetic Beads | HEK293 | Rhesus macaque |
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| SLX1B-4920H | Recombinant Human SLX1B Protein, GST-tagged | Wheat Germ | Human | GST |
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| SLX1B-5265R | Recombinant Rat SLX1B Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| SLX1B-5265R-B | Recombinant Rat SLX1B Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| SLX1B-5289HF | Recombinant Full Length Human SLX1B Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 275 amino acids |
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Involved Pathway
SLX1B involved in several pathways and played different roles in them. We selected most pathways SLX1B participated on our site, such as Fanconi anemia pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLX1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fanconi Anemia Pathway | RMI1,MUS81,EME2,FANCC,USP1,SLX4,FANCG,BRIP1,RMI2,FANCM |
Protein Function
SLX1B has several biochemical functions, for example, 5-flap endonuclease activity,crossover junction endodeoxyribonuclease activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SLX1B itself. We selected most functions SLX1B had, and list some proteins which have the same functions with SLX1B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| crossover junction endodeoxyribonuclease activity | GEN1 |
| protein binding | ITK,AKAP6,MATN3,CCDC110,NHP2,RUSC1-AS1,GAS6,FTCD,PTRF,PGF |
| 5-flap endonuclease activity | FAN1,FEN1,DNA2 |
| metal ion binding | SIRT7,ZNF574,BCO2,STAC,GGTA1,ARAP2,CYP46A1.1,ZFP879,ZC3H13,SPNA1 |
Interacting Protein
SLX1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLX1B here. Most of them are supplied by our site. Hope this information will be useful for your research of SLX1B.
SLX4;ERCC4;MUS81;GRB2;TUBA1B;ribF;q7ckh1_yerpe;sspA;q81zc1_bacan
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