SLC7A11
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Official Full Name
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -
Overview
This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. [provided by RefSeq, Sep 2011] -
Synonyms
SLC7A11;solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11;xCT;CCBR1;cystine/glutamate transporter;amino acid transport system xc-;solute carrier family 7 member 11;calcium channel blocker resistance protein CCBR1;solute carrier family 7, (cationic amino acid transporter, y+ system) member 11
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- HEK293
- Wheat Germ
- Mammalian Cell
- E.coli expression system
- E.coli
- In vitro E. coli expression system
- In Vitro Cell Free System
- Non
- GST
- His
- His&Fc&Avi
Involved Pathway
SLC7A11 involved in several pathways and played different roles in them. We selected most pathways SLC7A11 participated on our site, such as Amino acid transport across the plasma membrane,Basigin interactions,Cell surface interactions at the vascular wall, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC7A11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Basigin interactions | SLC3A2B,SLC7A6,ITGB1B.1,PPIA,SLC16A8,NADL1.1,SLC3A2A,BSG,SLC7A10,SLC7A8A |
| Amino acid transport across the plasma membrane | SLC38A4,SLC43A1B,SLC7A3A,SLC1A4,SLC38A3A,SLC6A19A,SLC43A2A,SLC43A2B,SLC36A2,SLC7A6 |
| Transport of inorganic cations/anions and amino acids/oligopeptides | SLC4A3,SLC43A1B,SLC6A20A,SLC9A5,SLC9A3.1,SLC6A19A,SLC20A1,SLC17A7A,SLC7A10,SLC24A4A |
| SLC-mediated transmembrane transport | SLC24A6,SLC2A8,SLC13A5,SLC6A20A,SLC1A2A,SLC31A1,SLC10A6,SLC15A1B,SLC38A3A,SLC15A3 |
| Cell surface interactions at the vascular wall | FCER1GL,JAM2B,SLC7A8A,ANGPT2A,DOK2,MERTK,CXADR,GRB14,PROCR,CEACAM6 |
| Hemostasis | CEACAM8,CLEC1B,GATA5,GNA13,HBB-BH1,HBE1,SERPINB8,TREM1,F13A1B,MAFGB |
| Transmembrane transport of small molecules | SLC4A2B,SLC6A7,ATP11C,SLC39A1,SLC26A7,SLC29A4,FTH1A,SLC5A9,SLC9A3.1,ASPH |
Protein Function
SLC7A11 has several biochemical functions, for example, cystine:glutamate antiporter activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC7A11 itself. We selected most functions SLC7A11 had, and list some proteins which have the same functions with SLC7A11. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | NR2C1,PRKAG1,RNF41,CXXC11,MPHOSPH6,ODF1,NCOR2,PARK2,CCDC130,PPP1R1A |
Interacting Protein
SLC7A11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC7A11 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC7A11.
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