SLC6A4
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Official Full Name
solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 -
Overview
This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma. -
Synonyms
SLC6A4;solute carrier family 6 (neurotransmitter transporter, serotonin), member 4;sodium-dependent serotonin transporter;5HTT;5HT transporter;solute carrier family 6 member 4;5-hydroxytryptamine (serotonin) transporter;Sodium-dependent serotonin t
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Chicken
- Cynomolgus
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- DDK
- Myc
- Non
- Avi
- Fc
- Flag
Involved Pathway
SLC6A4 involved in several pathways and played different roles in them. We selected most pathways SLC6A4 participated on our site, such as Serotonergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC6A4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Serotonergic synapse | SLC18A1,HTR2A,CYP2C70,GABRB1,CYP2C37,APP,CYP2D10,PLCB4,MAPK1,HTR5A |
Protein Function
SLC6A4 has several biochemical functions, for example, Rab GTPase binding,actin filament binding,cocaine binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC6A4 itself. We selected most functions SLC6A4 had, and list some proteins which have the same functions with SLC6A4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | P2RX4,CDK15,SMCR7,TUBA1B,RARS,MT3,TACR2,TREX1,HENMT1,IGF2 |
| nitric-oxide synthase binding | DNM3,CALM3,ACTB,SLC14A2,NOS1AP,ATP2B4,CDH2,CALM2,CD74,CAV3 |
| myosin binding | GIPC1,STX4A,VEZT,ARFGEF2,DMD,ACTA1,FXYD1,VAMP2,NPHS1,MYBPC3 |
| syntaxin-1 binding | STXBP3A,SYBU,SYT1,STXBP3,SNAP25A,CPLX1,VAMP3,GOLSYN,STXBP1,SNAP25B |
| actin filament binding | VPS16,ERMN,TAGLN3B,CORO2B,CTNNAL1,ADD2,CTNNA2,WIPF2,MYO3A,DBNLB |
| monoamine transmembrane transporter activity | SLC6A3,SLC18A2,SLC6A2,SLC29A4,SLC22A1,SLC18A1 |
| serotonin transmembrane transporter activity | SLC6A4A,SLC18A1,SLC6A4B |
| protein homodimerization activity | EXT1,SPATA24,SMAGP,BCL2A1,APOA4,DMRT3A,COMMD1,BMPR1A,PLEK,ADD2 |
| Rab GTPase binding | MICALL2,RAB3GAP2,RAB11FIP4B,ACAP2,RIMS1,EXPH5,MLPHB,PIFO,RAB8A,MYRIP |
Interacting Protein
SLC6A4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC6A4 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC6A4.
Gpm6b;imipramine;paroxetine;GPM6B;PICK1
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