SLC4A1
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Official Full Name
solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group) -
Overview
The protein encoded by this gene is part of the anion exchanger (AE) family and is expressed in the erythrocyte plasma membrane, where it functions as a chloride/bicarbonate exchanger involved in carbon dioxide transport from tissues to lungs. The protein comprises two domains that are structurally and functionally distinct. The N-terminal 40kDa domain is located in the cytoplasm and acts as an attachment site for the red cell skeleton by binding ankyrin. The glycosylated C-terminal membrane-associated domain contains 12-14 membrane spanning segments and carries out the stilbene disulphonate-sensitive exchange transport of anions. The cytoplasmic tail at the extreme C-terminus of the membrane domain binds carbonic anhydrase II. The encoded protein associates with the red cell membrane protein glycophorin A and this association promotes the correct folding and translocation of the exchanger. This protein is predominantly dimeric but forms tetramers in the presence of ankyrin. Many mutations in this gene are known in man, and these mutations can lead to two types of disease: destabilization of red cell membrane leading to hereditary spherocytosis, and defective kidney acid secretion leading to distal renal tubular acidosis. Other mutations that do not give rise to disease result in novel blood group antigens, which form the Diego blood group system. Southeast Asian ovalocytosis (SAO, Melanesian ovalocytosis) results from the heterozygous presence of a deletion in the encoded protein and is common in areas where Plasmodium falciparum malaria is endemic. One null mutation in this gene is known, resulting in very severe anemia and nephrocalcinosis. -
Synonyms
SLC4A1;solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group);AE1, DI, EPB3, Waldner blood group , WD;band 3 anion transport protein;CD233;FR;Froese blood group;RTA1A;SW;Swann blood group;WR;Wright blood group;Solute carrier family 4 anion exchanger member 1;Solute carrier family 4 member 1;AE 1;AE1;Anion exchange protein 1;Anion exchanger 1;B3AT_HUMAN;BND3;DI;Diego blood group;EMPB3;EPB3;Erythrocyte membrane protein band 3;Erythroid anion exchange protein;Waldner blood group;WD;WD1;OTTHUMP00000210781;solute carrier fa
Recombinant Proteins
- Human
- Mouse
- Rat
- Chicken
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- Mammalian cells
- His
- His&T7
- Non
- His&Fc&Avi
- His&Myc&SUMO
- His&Myc
- His&GST
- Myc&DDK
- Flag
Involved Pathway
SLC4A1 involved in several pathways and played different roles in them. We selected most pathways SLC4A1 participated on our site, such as Collecting duct acid secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC4A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Collecting duct acid secretion | ATP6V1G2,ATP6V0E,ATP6V1F,ATP6V1D,CA2,ATP6V1C2,ATP6V1G1,ATP6V1E1,ATP6V1B2,ATP6V0A1 |
Protein Function
SLC4A1 has several biochemical functions, for example, actin binding,anion transmembrane transporter activity,anion:anion antiporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC4A1 itself. We selected most functions SLC4A1 had, and list some proteins which have the same functions with SLC4A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| bicarbonate transmembrane transporter activity | SLC26A6,SLC4A11,SLC26A4,SLC26A3.2,SLC4A1B,SLC26A11,SLC26A1,SLC26A5,SLC26A3,SLC26A9 |
| anion transmembrane transporter activity | ABCA1,SLC4A11,SLC4A8,SLC4A1A,SLC4A2A,SLC4A1B,SLC4A4A,Slc4a2,SLC4A2B,SLC26A11 |
| anion:anion antiporter activity | SLC4A8,SLC26A2,SLC4A2A,SLC26A3.1,SLC26A7,SLC26A1,SLC26A4,SLC4A11,SLC26A6L,SLC26A9 |
| chloride transmembrane transporter activity | SLC26A3,SLC26A6,SLC26A1,CFTR,SLC26A4,Slc4a2 |
| ankyrin binding | CDH1,OBSCN,PLEC,SCN5A,SLC8A1,RHCG,PTBP3,KCNJ11,FLNC,KCNQ2 |
| inorganic anion exchanger activity | SLC4A4,SLC22A20,SLC22A8,SLC4A8,SLC4A1A,SLC22A6,SLC22A9,SLC4A2B,SLC22A24,SLC4A4A |
| protein binding | TMEM194,FAM86C,BNIP2,NBR1,ALPP,RTN3,SIRT1,RAB1B,TRIP10,GTF3C3 |
| actin binding | CNN3,MYH1E,TMOD2,MSRB1,MSNB,SPTBN1,STRC,FXYD5,FHL3,XIRP2 |
| protein C-terminus binding | AP2A1,JAK2,DDX1,ZBTB16,KCNIP3,PIAS4,RABAC1,CORO1A,ITPR1,NCL |
Interacting Protein
SLC4A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC4A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC4A1.
ATP1B1;CDKN2A;PTPN1;ATP1A1;PTPN11;CDKN2A
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