SLC16A1
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Official Full Name
solute carrier family 16 (monocarboxylate transporter), member 1 -
Overview
The protein encoded by this gene is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Mutations in this gene are associated with erythrocyte lactate transporter defect. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2009] -
Synonyms
SLC16A1;solute carrier family 16 (monocarboxylate transporter), member 1;MCT;HHF7;MCT1;monocarboxylate transporter 1;MCT 1;solute carrier family 16 member 1;solute carrier family 16 (monocarboxylic acid transporters), member 1;solute carrier family 16, member 1 (monocarboxylic acid transporter 1)
Recombinant Proteins
- Zebrafish
- Chicken
- Mouse
- Rhesus macaque
- Rat
- Human
- Meriones unguiculatus (Mongolian jird) (Mongolian gerbil)
- Mammalian Cell
- HEK293
- E.coli expression system
- Insect Cell
- E.coli
- Wheat Germ
- HEK293T
- In Vitro Cell Free System
- Mammalian cells
- His
- Non
- His&Flag&Strep
- His&SUMO
- His&Fc&Avi
- GST
- Myc&DDK
- Flag
Involved Pathway
SLC16A1 involved in several pathways and played different roles in them. We selected most pathways SLC16A1 participated on our site, such as Basigin interactions,Cell surface interactions at the vascular wall,Hemostasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC16A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism | Alb,SLC25A15B,TCN1,PHOSPHO1,SLC6A8,GCKR,PAOX,CYP24A1,MED23,ACOT6 |
| Pyruvate metabolism | DLAT,PKMB,PDHA1A,ALDH2.2,ackA,ACSS2L,ALDH2,ACYP1,ACACB,PKLR |
| Cell surface interactions at the vascular wall | BSG,JAM2B,TREM1,FCER1GL,CD84,GLG1B,GRB14,ITGB1B.1,SLC7A10,ESAMA |
| Hemostasis | DOCK6,PROCR,RAPGEF3,ITPK1,KIF4,SPARC,KIF18A,KIF2B,KIF11,BRPF3 |
| Basigin interactions | PPIA,SLC7A11,SLC7A8A,SLC3A2B,BSG,NADL1.1,SLC7A10,SLC3A2A,SLC16A8,SLC7A6 |
| Proton-coupled monocarboxylate transport | SLC16A7,SLC16A8 |
| Pyruvate metabolism and Citric Acid (TCA) cycle | PDK2,PDPR,PDK4,SLC16A8,PDK3,BRP44,PDK2B,PDP2,D2HGDH,ADHFE1 |
| SLC-mediated transmembrane transport | SLC15A1B,SLCO4C1,SLC7A10,SLC1A4,LCN15,SLC35A3B,SLC2A6,SLC2A8,SLC20A1,SLC35A1 |
Protein Function
SLC16A1 has several biochemical functions, for example, lactate transmembrane transporter activity,mevalonate transmembrane transporter activity,monocarboxylic acid transmembrane transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC16A1 itself. We selected most functions SLC16A1 had, and list some proteins which have the same functions with SLC16A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| lactate transmembrane transporter activity | SLC16A5,SLC16A12,SLC16A7,SLC16A3,SLC5A12,SLC16A12B,SLC16A8 |
| protein homodimerization activity | GCA,GSTA4,GALE,SMAD2,TCF3,RELA,Anks6,AADAT,MTMR2,ACAT1 |
| monocarboxylic acid transmembrane transporter activity | SLC16A6A,SLC16A9,SLC16A4,SLC16A9B,SLCO1A5,SLC16A13,SLC16A6,SLC16A9A,PPP1R42,SLC16A3 |
| organic cyclic compound binding | MTNR1A |
| symporter activity | SLC15A5,SLC1A3A,SLC34A3,MFSD2A,SLC16A6,SLC1A3B,SLC10A5,SLC5A8L,SLC1A8B,SLC6A19A |
Interacting Protein
SLC16A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC16A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC16A1.
DEGS1;AP1S1;SERINC3;TSC22D1;TRAF6;ugpA;MME;Bmpr1a;ILK;Map3k12;P;FAM46A;MAP1LC3B
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References
- Palladino, AA; Bennett, MJ; et al. Hyperinsulinism in infancy and childhood: when an insulin level is not always enough. ANNALES DE BIOLOGIE CLINIQUE 67:245-254(2009).
- Palladino, AA; Bennett, MJ; et al. Hyperinsulinism in infancy and childhood: When an insulin level is not always enough. CLINICAL CHEMISTRY 54:256-263(2008).
- Ahlin, G; Hilgendorf, C; et al. Endogenous Gene and Protein Expression of Drug-Transporting Proteins in Cell Lines Routinely Used in Drug Discovery Programs. DRUG METABOLISM AND DISPOSITION 37:2275-2283(2009).
- Palladino, AA; Bennett, MJ; et al. Hyperinsulinism in infancy and childhood: when an insulin level is not always enough. LABORATORIUMSMEDIZIN-JOURNAL OF LABORATORY MEDICINE 33:170-U3(2009).
