SH2D1A
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Official Full Name
SH2 domain containing 1A -
Overview
SH2D1A and SH2D1B are small, adaptor proteins with a single SH2-domain that play important signal transduction roles mediated by the signaling lymphocytic activation molecule (SLAM) family receptors. SH2D1A (also called SAP or SLAM-associated protein) is -
Synonyms
SH2D1A;SH2 domain containing 1A;IMD5, lymphoproliferative syndrome , LYP, SH2 domain protein 1A;SH2 domain-containing protein 1A;DSHP;Duncans disease;EBVS;MTCP1;SAP;XLP;XLPD;SLAM-associated protein;Duncan disease SH2-protein;T cell signal transduction molecule SAP;T-cell signal transduction molecule SAP;SLAM associated protein/SH2 domain protein 1A;signaling lymphocyte activation molecule-associated protein;signaling lymphocytic activation molecule-associated protein;LYP;IMD5;SAP/SH2D1A;FLJ18687;FLJ92177
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cell
- Human
- HEK293
- HEK293T
- GST
- His
- Non
- His&T7
- Myc&DDK
- His&Fc&Avi
Involved Pathway
SH2D1A involved in several pathways and played different roles in them. We selected most pathways SH2D1A participated on our site, such as Natural killer cell mediated cytotoxicity,Measles, which may be useful for your reference. Also, other proteins which involved in the same pathway with SH2D1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Natural killer cell mediated cytotoxicity | PRKCA,PLCG1,ARAF,ULBP2,VAV3,KLRD1,BID,ICAM1,ZAP70,PRF1 |
| Measles | PIK3R5,TYK2,MAP3K7,CBLB,CD3D,HSPA6,PIK3R3,NFKBIB,IL2RB,TLR7 |
Protein Function
SH2D1A has several biochemical functions, for example, SH3/SH2 adaptor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SH2D1A itself. We selected most functions SH2D1A had, and list some proteins which have the same functions with SH2D1A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | CEP104,Ctsl,RIPK1L,DAPK3,SGCA,LRP12,UNC45A,CD9,IL2RB,DKC1 |
| SH3/SH2 adaptor activity | SHB,STAM,GRAP,IRS4,KHDRBS1,NCK2,GRB14,NCK1,SH2D2A,LAT |
Interacting Protein
SH2D1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SH2D1A here. Most of them are supplied by our site. Hope this information will be useful for your research of SH2D1A.
SLAMF1;ARHGEF7
Resources
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References
- Simon, KC; Schmidt, H; et al. Epstein-Barr virus candidate genes and multiple sclerosis. MULTIPLE SCLEROSIS AND RELATED DISORDERS 4:60-64(2015).
- Meazza, R; Tuberosa, C; et al. XLP1 inhibitory effect by 2B4 does not affect DNAM-1 and NKG2D activating pathways in NK cells. EUROPEAN JOURNAL OF IMMUNOLOGY 44:1526-1534(2014).
