SCARB1
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Official Full Name
scavenger receptor class B, member 1 -
Overview
Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Receptor for hepatitis C virus glycoprotein E2. Binding between SCARB1 and E2 was found to be independent of the genotype of the viral isolate. Plays an important role in the uptake of HDL cholesteryl ester. -
Synonyms
SCARB1;scavenger receptor class B, member 1;CD36;Cla1;SRBI;Srb1;Cla-1;Hdlq1;SR-B1;SR-BI;Cd36l1;Hlb398;mSR-BI;AI120173;D5Ertd460e;scavenger receptor class B member 1;HDL QTL 1;scavenger receptor class B1;scavenger receptor class B type I
Recombinant Proteins
- Human
- Mouse
- Rat
- Zebrafish
- HEK293
- E.coli
- Human Cell
- Mammalian Cell
- Human
- HEK293T
- Mammalian cells
- His
- His&GST
- Fc
- His&Fc
- Non
- His&Avi
- His&SUMO
- Myc&DDK
- His&Fc&Avi
Involved Pathway
SCARB1 involved in several pathways and played different roles in them. We selected most pathways SCARB1 participated on our site, such as Phagosome,Ovarian steroidogenesis,Aldosterone synthesis and secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with SCARB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fat digestion and absorption | DGAT2,ABCA1,DGAT1,PLA2G2D,FABP1,PNLIPRP2,APOA4,Cel,CLPS,PLA2G2A |
| Ovarian steroidogenesis | Adcy4,LDLR,AKR1C3,HSD17B2,LHB,HSD17B7,PRKACB,INS1,ALOX5,HSD3B1 |
| Aldosterone synthesis and secretion | CAMK2D,Adcy4,CYP21A1,PRKCG,CALM3,KCNK9,PRKD3,CREB3L4,ORAI1,AGTR1B |
| Hepatitis C | IFNA5,CLDN11,CLDN14,MAPK10,PIAS1,CLDN1,TLR3,IFNA16,RELA,PPP2CB |
| Bile secretion | SLC51A,OSTA,SLC4A4,NR1H4,AQP1,SLC22A1,ADCY6,Car2,SLCO1A5,Slc4a2 |
| Phagosome | SEC22BA,CORO1A,RAB7A,TUBA8L3,CTSLA,NOS1,PIKFYVE,TUBA1L2,SFTPD,ATP6V1B1 |
| Vitamin digestion and absorption | PNLIP,APOA4,SLC5A6,BTD,LMBRD1,SLC23A1,APOB,SLC19A3,SLC19A2,FOLH1 |
Protein Function
SCARB1 has several biochemical functions, for example, 1-phosphatidylinositol binding,apolipoprotein A-I binding,apolipoprotein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SCARB1 itself. We selected most functions SCARB1 had, and list some proteins which have the same functions with SCARB1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | DPM1,SH3YL1,THRB,SLC25A10,ANKFY1,GGA3,ARRB2,CTNND1,PPID,NDUFS1 |
| lipopolysaccharide binding | SELP,CD14,TLR4,TREM2,CATHL3,RNASE7,TRIL,PTAFR,PSMB4,BPI |
| transporter activity | CRABP2,RBP2B,ASNA1,CDH17,PTGDSB,SYPA,SLC4A1B,SLCO1B2,CRABP1A,SLCO1F1 |
| 1-phosphatidylinositol binding | SNX9,CCDC167,SCIN,EEA1,SYT1,WDFY3,PICALM,ZFYVE16,PLEKHA4,ZFYVE9 |
| apolipoprotein A-I binding | LCAT,ABCA1,ABCA1B |
| high-density lipoprotein particle receptor activity | ILDR1 |
| phosphatidylserine binding | SYTL2,FCHO2,CPNE1,SCIN,CPNE6,ANXA9,SYT4,ANXA13,AXL,RASGRP1 |
| virus receptor activity | CR1,SERPINB3,ITGA5,TFRC,XPR1,CLEC4M,TYRO3,ACE2,LAMP1,HTR2A |
| apolipoprotein binding | CANX,LIPC,VLDLR,LRP4,LRP1,PLG,PCSK9,LPL,LRP6,MAPT |
Interacting Protein
SCARB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SCARB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SCARB1.
KRTAP5-9;KRTAP10-9;1-hexadecanoyl-2-(9z-octadecenoyl)-sn-glycero-3-phosphocholine;p27958-pro_0000037570;APOA1;p26663-pro_0000037533;PRMT2;cona_canen;FLT1
Resources
Research Area
Lipoprotein Receptors and Associated ProteinsUptake and Transport Molecules on Endothelial Cells
Uptake and Transport Molecules in VSMC
Scavenger Receptors
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References
