S100A7
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Official Full Name
S100 calcium binding protein A7 -
Overview
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein differs from the other S100 proteins of known structure in its lack of calcium binding ability in one EF-hand at the N-terminus. This protein is markedly over-expressed in the skin lesions of psoriatic patients, but is excluded as a candidate gene for familial psoriasis susceptibility. The exact function of this protein is not known. [provided by RefSeq, Jul 2008] -
Synonyms
S100A7;S100 calcium binding protein A7;PSOR1;S100A7c;protein S100-A7;psoriasin 1;S100 calcium-binding protein A7 (psoriasin 1)
Recombinant Proteins
- Human
- Cattle
- Bovine
- E.coli
- Wheat Germ
- HEK293
- Mouse
- Rabbit
- HEK293F
- HEK293T
- In Vitro Cell Free System
- Mammalian cells
- GST
- Non
- His
- His&GST
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
S100A7 involved in several pathways and played different roles in them. We selected most pathways S100A7 participated on our site, such as Validated targets of C-MYC transcriptional repression, which may be useful for your reference. Also, other proteins which involved in the same pathway with S100A7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Validated targets of C-MYC transcriptional repression | CLU,LGALS1,MXD4,NDRG1,DNTT,GFI1,TMEFF2,ZFP36L1,CSDE1,TMEM126A |
Protein Function
S100A7 has several biochemical functions, for example, RAGE receptor binding,calcium ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by S100A7 itself. We selected most functions S100A7 had, and list some proteins which have the same functions with S100A7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | MFGE8A,ANXA11,SULF1,PCDHB11,PCDHGA4,EDEM2,OTOF,CETN1,PCDHA2,CELSR2 |
| RAGE receptor binding | S100A8,S100A13,HMGB1,HMGB2,FPR1,S100A12,S100A9,S100B,S100P,S100A4 |
| protein binding | C17orf28,LMX1B,MBD3,RFPL4,L3MBTL3,YTHDC1,JAKMIP1,NCF1,CCL28,CLDN2 |
| zinc ion binding | TRIM108,ASTL,RARGA,TRIM14,CAR7,BIRC8,PARK2,XIRP2,MMP1,TRAF4 |
Interacting Protein
S100A7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with S100A7 here. Most of them are supplied by our site. Hope this information will be useful for your research of S100A7.
RANBP9;PPP2R2B;MAP3K3;PAK7;RASSF10;RASSF9;ESR1;IFIT1;CFTR;VCAM1;CD81;P/V/C;K3
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References
- Lapeire, L; Hendrix, A; et al. Cancer-Associated Adipose Tissue Promotes Breast Cancer Progression by Paracrine Oncostatin M and Jak/STAT3 Signaling. CANCER RESEARCH 74:6806-6819(2014).
- Witte, E; Kokolakis, G; et al. IL-19 Is a Component of the Pathogenetic IL-23/IL-17 Cascade in Psoriasis. JOURNAL OF INVESTIGATIVE DERMATOLOGY 134:2757-2767(2014).
