Rtn4
-
Official Full Name
reticulon 4 -
Overview
This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous system in higher vertebrates. Alternatively spliced transcript variants derived both from differential splicing and differential promoter usage and encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] -
Synonyms
RTN4;reticulon 4;ASY;NSP;NOGO;NOGOC;RTN-X;NOGO-A;NSP-CL;Nogo-B;Nogo-C;RTN4-A;RTN4-C;RTN4-B1;RTN4-B2;NI220/250;Nbla00271;Nbla10545;reticulon-4;foocen;Human NogoA;reticulon 5;My043 protein;neurite outgrowth inhibitor;neurite growth inhibitor 220;neuroendocrine-specific protein C homolog
Recombinant Proteins
- Rat
- Human
- Rhesus macaque
- Chicken
- Mouse
- Mammalian Cells
- E.coli
- HEK293
- Fc
- GST
- His
- Non
- Avi&His&Fc
- His&GST
- Myc&DDK
- His&Fc&Avi
Involved Pathway
Rtn4 involved in several pathways and played different roles in them. We selected most pathways Rtn4 participated on our site, such as Axonal growth inhibition (RHOA activation),Signal Transduction,Signalling by NGF, which may be useful for your reference. Also, other proteins which involved in the same pathway with Rtn4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signal Transduction | RGS20,RDH13,AKAP13,PTHLHA,ARHGEF18,NPS,ARHGAP19,TAGAPA,PYY,LRIG1 |
| Spinal Cord Injury | RTN4R,RGMA,GDNF,LILRB3,NOX4,LGALS3,GAP43,TNFSF13B,OMG,MBP |
| Axonal growth inhibition (RHOA activation) | ARHGEF1B,RTN4A,OMG,LINGO1B,LINGO1 |
| p75 NTR receptor-mediated signalling | AATF,ARHGEF1B,OMG,LINGO1B,RTN4A,PRDM4,LINGO1 |
| p75(NTR)-mediated signaling | BEX1,OMG,MAGEH1,NDN,RTN4R,PRDM4,ZNF274 |
| Signalling by NGF | RIT2,OMG,RIT1,LINGO1B,RTN4A,AATF,PCSK6,PCSK5,PRDM4,LINGO1 |
| p75NTR regulates axonogenesis | RTN4A,OMG,ARHGEF1B,LINGO1B,LINGO1 |
Protein Function
Rtn4 has several biochemical functions, for example, poly(A) RNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Rtn4 itself. We selected most functions Rtn4 had, and list some proteins which have the same functions with Rtn4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | CCL18,DR1,PDIA3,NUP133,LEO1,CDKN2B,MAP2K4,IL5RA,ASXL1,HUWE1 |
| poly(A) RNA binding | ESF1,GRWD1,UPF1,CSTF1,IMP3,UBE2O,PUS1,TCERG1,GTPBP4,SECISBP2 |
Interacting Protein
Rtn4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Rtn4 here. Most of them are supplied by our site. Hope this information will be useful for your research of Rtn4.
SNX15;NCK2;SNX1;ARL6IP1;SYT16;ZFYVE21;RTN3
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References
- Herskowitz, JH; Seyfried, NT; et al. Phosphoproteomic Analysis Reveals Site-Specific Changes in GFAP and NDRG2 Phosphorylation in Frontotemporal Lobar Degeneration. JOURNAL OF PROTEOME RESEARCH 9:6368-6379(2010).
- Klinger, M; Diekmann, H; et al. Identification of two nogo/rtn4 genes and analysis of Nogo-A expression in Xenopus laevis. MOLECULAR AND CELLULAR NEUROSCIENCE 25:205-216(2004).
