Rcan2
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Official Full Name
regulator of calcineurin 2 -
Overview
This gene encodes a member of the regulator of calcineurin (RCAN) protein family. These proteins play a role in many physiological processes by binding to the catalytic domain of calcineurin A, inhibiting calcineurin-mediated nuclear translocation of the transcription factor NFATC1. Expression of this gene in skin fibroblasts is upregulated by thyroid hormone, and the encoded protein may also play a role in endothelial cell function and angiogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. -
Synonyms
RCAN2;regulator of calcineurin 2;Down syndrome critical region gene 1 like 1 , DSCR1L1;calcipressin-2;ZAKI 4;Calcipressin 2;CSP2;Down syndrome candidate region 1-like 1;Down syndrome critical region gene 1 like 1 protein;MCIP2;Myocyte enriched calcineurin interacting protein 2;Myocyte-enriched calcineurin-interacting protein 2;RCAN2_HUMAN;RCN2;Thyroid hormone responsive protein ZAKI4;Thyroid hormone-responsive protein ZAKI-4;ZAKI4;Down syndrome critical region gene 1-like 1;thyroid hormone-responsive (skin fibroblasts);ZAKI-4;DSCR1L1
Recombinant Proteins
- Zebrafish
- Human
- Rat
- Mammalian Cell
- E.coli
- Wheat Germ
- Human
- HEK293
- In Vitro Cell Free System
- His
- GST
- Non
- His&Fc&Avi
- His&GST
Involved Pathway
Rcan2 involved in several pathways and played different roles in them. We selected most pathways Rcan2 participated on our site, such as Calcium signaling in the CD4+ TCR pathway,Role of Calcineurin-dependent NFAT signaling in lymphocytes,Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Rcan2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Role of Calcineurin-dependent NFAT signaling in lymphocytes | CHP,RCAN1,FKBP8 |
| Calcium signaling in the CD4+ TCR pathway | RCAN1,AKAP5,CHP,CSF2,FKBP1A,JUNB,BATF3,POU2F1 |
| Thyroid hormone signaling pathway | PIK3CB,RHEB,PIK3CG,MED1,MAP2K1,ATP1B2,MDM2,MED13L,ITGB3,NOTCH3 |
Protein Function
Rcan2 has several biochemical functions, for example, calcium-dependent protein serine/threonine phosphatase regulator activity,nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Rcan2 itself. We selected most functions Rcan2 had, and list some proteins which have the same functions with Rcan2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| nucleotide binding | SRSF2A,CAMK2B1,SBK3,CSNK2A2A,RHOAD,RAB14L,NT5C1A,RAB11AL,ARL5C,RBM4.2 |
| calcium-dependent protein serine/threonine phosphatase regulator activity | RCAN1A,RCAN3,RCAN1 |
Interacting Protein
Rcan2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Rcan2 here. Most of them are supplied by our site. Hope this information will be useful for your research of Rcan2.
TCEB1
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References
- Qin, WP; Pan, JP; et al. Anabolic steroids activate calcineurin-NFAT signaling and thereby increase myotube size and reduce denervation atrophy. MOLECULAR AND CELLULAR ENDOCRINOLOGY 399:336-345(2015).
- Skoda, G; Kerekes, A; et al. Examination of a regulatory SNP of bovine RCAN2 gene in transgenic mouse models. TRANSGENIC RESEARCH 23:889-889(2014).
