RIPK3
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Official Full Name
receptor-interacting serine-threonine kinase 3 -
Overview
Receptor-interacting protein 3 (RIP3) contains a N-terminal kinase domain and interacts with RIP. The binding of RIP to RIP3 causes the RIP3/RIP complex to be shuttled into the tumor necrosis factor receptor-1 signaling cascade. RIP3 is known to be a very effective apoptosis inducer. Two novel splice variants of RIP3 have been discovered, RIP3 beta and RIP3 gamma, that have shown to decrease apoptosis related to full length RIP3. RIP3 gamma has been shown to be significantly up-regulated in colon and lung cancers and may play a role in tumorigenesis. -
Synonyms
RIPK3;receptor-interacting serine-threonine kinase 3;receptor-interacting serine/threonine-protein kinase 3;RIP3;RIP-3;RIP-like protein kinase 3;receptor interacting protein 3;receptor-interacting protein 3
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Insect Cell
- Wheat Germ
- Mammalian Cell
- Sf9 Insect Cell
- HEK293
- Yeast
- In Vitro Cell Free System
- GST
- His
- His&T7
- Non
- His&GST
- His&Myc
- His&Fc&Avi
- His&SUMO
Involved Pathway
RIPK3 involved in several pathways and played different roles in them. We selected most pathways RIPK3 participated on our site, such as Activated TLR4 signalling,Cytosolic DNA-sensing pathway,Cytosolic sensors of pathogen-associated DNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with RIPK3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Programmed Cell Death | Gzmg,STK24B,DIABLOA,DSG1,PLECA,PANK1A,GZME,STK24,STK26,GZMF |
| MyD88-independent TLR3/TLR4 cascade | TANK |
| Innate Immune System | DDX41,S100A12,NLRP4E,DEFB106A,MB21D1,CTSK,TLR10,BTR29,BTR02,CYLD |
| Activated TLR4 signalling | DUSP6,TLR6,DUSP4,S100A12,TANK,CHST13,DUSP3,TICAM1,ALCAMB,MAP3K8 |
| Cytosolic sensors of pathogen-associated DNA | POLR3F,POLR3C,AGER,LRRFIP1,S100A12,APPA,DDX41,TICAM1,APPB,CRCP |
| Immune System | CD200R4,KIF5A,UBE2F,TRIM22,UBR1,BTR06,CNPY3,EVL,ART1,DEFB116 |
| Cytosolic DNA-sensing pathway | IFNA7,CCL4,RELA,POLR2K,DDX58,IFNPHI1,POLR3GL,IFNA10,IFNA3,POLR3B |
Protein Function
RIPK3 has several biochemical functions, for example, ATP binding,NF-kappaB-inducing kinase activity,identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RIPK3 itself. We selected most functions RIPK3 had, and list some proteins which have the same functions with RIPK3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription coactivator activity | TFAP2B,GTF2F1,IL31RA,TAF6L,GATA4,TRIP4,TFDP1A,MAML2,ASXL1,RNF20 |
| protein kinase activity | CDK14,PRKCI,PIK3R4,STK17B,MAPKAPK2B,STK4,ERBB3B,TGFBR1A,INSRB,SBK3 |
| protein serine/threonine kinase activity | ADCK5,STK31,NEK3,AKT1,NEK1,NEK2,TTN,SRPK1,PAK7,AURKA |
| protein binding | GCA,NPY1R,MAP1LC3B,L3MBTL3,DNAJB9,KLHL35,RPL14,KAT2B,CCDC135,CTSL1 |
| ATP binding | DDX19A,P2RX4A,PI4KA,DDX58,TNK1,NETO2,YME1L1,NLRP3,NUBP2,FDXACB1 |
| NF-kappaB-inducing kinase activity | PPP4C,ALPK2,IRAK1,ALK,MAP3K14,IKBKE |
| identical protein binding | C1QTNF6,GBP1,CIDEB,C1QL4,L1CAM,ADORA2A,UBE4A,NME1,GNPNAT1,STK10 |
| protein complex binding | TUBB,TXN2,FLCN,PTCH1,NDUFA8,PAFAH1B1,LRP1,CEBPA,CDKN1A,RPTOR |
Interacting Protein
RIPK3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RIPK3 here. Most of them are supplied by our site. Hope this information will be useful for your research of RIPK3.
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