RHOC
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Official Full Name
ras homolog family member C -
Overview
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The protein encoded by this gene is prenylated at its C-terminus, and localizes to the cytoplasm and plasma membrane. It is thought to be important in cell locomotion. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008] -
Synonyms
RHOC;ras homolog family member C;H9;ARH9;ARHC;RHOH9;rho-related GTP-binding protein RhoC;rhoC GTPase;oncogene RHO H9;rho cDNA clone 9;RAS-related homolog 9;small GTP binding protein RhoC;ras homolog gene family, member C
Recombinant Proteins
- Human
- Mouse
- Chicken
- E.coli
- Mammalian Cell
- HEK293
- Mammalian cells
- HEK293T
- GST
- His
- Non
- Flag
- His&Fc&Avi
- Myc&DDK
Involved Pathway
RHOC involved in several pathways and played different roles in them. We selected most pathways RHOC participated on our site, such as Axon guidance,Developmental Biology,G alpha (12/13) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with RHOC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RHO GTPases Activate ROCKs | RHOAE |
| RHO GTPases Activate Formins | AHCTF1,DIAPH1,DSN1,RCC2,ZWILCH,SPDL1,RHOAE,NUF2,NDEL1B,CLIP1 |
| Developmental Biology | MYOD1,DUSP4,CSNK2B,PEA15,NRP1A,EFNA5,CLASP1,TRPC7,SPTB,CACNG2B |
| RHO GTPases Activate Rhotekin and Rhophilins | RHPN2,TAX1BP3,LIN7B,ROPN1,RTKN,RHPN1 |
| Axon guidance | ROBO1,PAK3,TRPC4,RNF8,PPP3CB,EPHB3,ABL1,ANK2B,L1CAM,HFE2 |
| GPCR downstream signaling | NMU,NMUR1,GPBAR1,TAC3,ADORA2B,VIP,PYY,CALCB,EDNRA,GPR55 |
| G alpha (12/13) signalling events | RHOB,TRIO,ARHGEF1A,PLEKHG2,ARHGEF17,AKAP13,ARHGEF9,FGD2,FGD4A,ARHGEF3 |
| RHO GTPase Effectors | RCC2,WASF3,ZWINT,ROPN1,KDM4C,DIAPH1,ACTR2B,MKL1B,NDEL1B,KLC3 |
Protein Function
RHOC has several biochemical functions, for example, GTP binding,protein binding,signal transducer activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RHOC itself. We selected most functions RHOC had, and list some proteins which have the same functions with RHOC. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| signal transducer activity | SLC35B2,TAS2R125,ITGB3BP,TRAF5,OLFCW1,TAAR7A,TAAR14G,CANT1,CAPN3,C18orf32 |
| GTP binding | SAR1AB,RAB37,ARL5C,REM2,MOCS1,RTKN,MX2,TUBA8L,HBS1L,TUBB4A |
| protein binding | ENC1,PIBF1,HSCB,TSC22D1,IL2RB,ATP6AP2,FBXW9,EIF4EBP1,MATK,HSPA5 |
Interacting Protein
RHOC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RHOC here. Most of them are supplied by our site. Hope this information will be useful for your research of RHOC.
FAM65B;env;Diaph1;DIAPH1;sseJ;DAAM1;GH1;MCC;VHL;ARHGDIA;IKBKE;CNKSR1;PINX1;TRAF6;ARHGAP1
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References
- Chinestra, P; Olichon, A; et al. Generation of a Single Chain Antibody Variable Fragment (scFv) to Sense Selectively RhoB Activation. PLOS ONE 9:-(2014).
- Zhao, ZH; Tian, Y; et al. RhoC, vascular endothelial growth factor and microvascular density in esophageal squamous cell carcinoma. WORLD JOURNAL OF GASTROENTEROLOGY 21:905-912(2015).
