RGS2
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Official Full Name
regulator of G-protein signaling 2, 24kDa -
Overview
Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins;(GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of;the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of;G protein signaling 2 belongs to this family. The protein acts as a mediator of myeloid differentiation and may play a;role in leukemogenesis. -
Synonyms
RGS2;regulator of G-protein signaling 2, 24kDa;G0S8, regulator of G protein signalling 2, 24kD , regulator of G protein signalling 2, 24kDa;regulator of G-protein signaling 2;G0/G1 switch regulatory protein 8;cell growth-inhibiting protein 31;G0 t
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Chicken
- Zebrafish
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- GST
- T7
- Non
- His
- His&SUMO
- His&Fc&Avi
- Myc&DDK
Involved Pathway
RGS2 involved in several pathways and played different roles in them. We selected most pathways RGS2 participated on our site, such as cGMP-PKG signaling pathway,Olfactory transduction,Oxytocin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RGS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Olfactory transduction | OR1A2,OR51B5,GNB1,OLFR998,OLFR510,OLFR11,PRKACB,OR8B8,SLC24A4,OR1L1 |
| cGMP-PKG signaling pathway | NPR2,ATP1A4,GNAI3,PPP3CC,INS2,BAD,GTF2IRD1,AGTR1A,ATP1A3,MAPK3 |
| Oxytocin signaling pathway | TRPM2,MYL9,PPP1R12C,PLA2G4C,ROCK1,PPP1CA,PRKACB,PRKACG,CACNG8,PPP3CC |
Protein Function
RGS2 has several biochemical functions, for example, GTPase activator activity,beta-tubulin binding,calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RGS2 itself. We selected most functions RGS2 had, and list some proteins which have the same functions with RGS2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| beta-tubulin binding | SERPINB1A,PACRG,PDCD5,SPAST,PEX14,TRPV4,TBCD,GABARAPL2,UXT,ARL8B |
| calmodulin binding | ADD1,KCNN3,UBR4,GEM,NRGNA,SPTBN1,SNTB1,MYLK2,MYH9,SNTA1 |
| GTPase activator activity | RAB3GAP2,ARHGAP1,TBC1D1,ARHGAP44,TBC1D25,RGS13,PLCB1,TBC1D2,ALDH1A1,ADAP1 |
| protein binding | ILKAP,EPN3,SLAMF1,WARS,PIAS2,ACTN3,RPN1,PALM,ZMYND10,BLOC1S4 |
Interacting Protein
RGS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RGS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of RGS2.
LRRK2;MTUS2;PARK2;CTSB;HSPA8;PRKCSH;DYNLL1;DDR1
Resources
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References
- Puard, V; Tranchant, T; et al. Semi-quantitative measurement of specific proteins in human cumulus cells using reverse phase protein array. REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY 11:-(2013).
