RARG

  • Official Full Name

    retinoic acid receptor, gamma

  • Overview

    This gene encodes a retinoic acid receptor that belongs to the nuclear hormone receptor family. Retinoic acid receptors (RARs) act as ligand-dependent transcriptional regulators. When bound to ligands, RARs activate transcription by binding as heterodimers to the retinoic acid response elements (RARE) found in the promoter regions of the target genes. In their unbound form, RARs repress transcription of their target genes. RARs are involved in various biological processes, including limb bud development, skeletal growth, and matrix homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

  • Synonyms

    RARG;retinoic acid receptor, gamma;retinoic acid receptor gamma;NR1B3;RARC;Nuclear receptor subfamily 1 group B member 3;RAR gamma;Retinoic acid receptor gamma 1;Retinoic acid receptor gamma 2;Retinoic acid receptor gamma polypeptide;RAR-gamma;OTTHUMP00000045736;OTTHUMP00000241950;OTTHUMP00000241951;OTTHUMP00000241952;retinoic acid nuclear receptor gamma variant 1;retinoic acid nuclear receptor gamma variant 2

Recombinant Proteins

  • Human
  • Mouse
  • E.coli
  • Sf9 Cells
  • Insect Cells
  • Mammalian Cells
  • HEK293
  • GST
  • Non
  • His
  • Myc&DDK
  • His&Fc&Avi

    Involved Pathway

    RARG involved in several pathways and played different roles in them. We selected most pathways RARG participated on our site, such as Gene Expression,Generic Transcription Pathway,Nuclear Receptor transcription pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RARG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Nuclear Receptor transcription pathway NR2F1A,NR6A1,NR1D2,NR1H3,NRBP1,NR2C2,NR2F6A,NR0B2A,NRBF2,VDRB
    Vitamin A and carotenoid metabolism RDH10,BCO2,RBP7,CRABP2,DHRS3,RDH12,CRABP1
    Generic Transcription Pathway ZNF764,CCNT2B,ZNF468,ZNF79,ZNF563,ZNF274,ZNF12,ZNF263,ZNF615,ZNF548
    Signaling by Retinoic Acid AKR1C6,RDH14B,PDK2B,RDH13,CRABP1,DHRS3,RDH10,CRABP1A,DHRS4,PDK3B
    Gene Expression ZNF70,LAMTOR1,ZFP28,TRIM28,ZNF287,ZNF547,TRMT61A,ZNF620,ZNF624,ZNF443
    Nuclear receptors in lipid metabolism and toxicity NR1I3,ABCC2,RARGA,CYP24A1,CYP26A1,VDRB,NR1I2,RARGB,CYP27B1
    Nuclear Receptors NR0B1,NR2C2,NR1D2,RORAA,VDRB,NR2F1A,NR2F6,NR2F2,NR2F1,RARGA
    Signal Transduction RDH14A,FSTL1,PRICKLE1B,RSPO1,PPY,FGD2,UCHL5,CDC42EP3,THBS3B,EVC2

    Protein Function

    RARG has several biochemical functions, for example, DNA binding,RNA polymerase II regulatory region sequence-specific DNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RARG itself. We selected most functions RARG had, and list some proteins which have the same functions with RARG. You can find most of the proteins on our site.

    Function Related Protein
    transcription factor activity, sequence-specific DNA binding HCFC1,TFDP2,TBX21,FOXO3B,RXRAA,NR5A1A,FOXQ1B,SMAD3A,IRF1A,ETV5
    zinc ion binding PGR,GCM1,PAPLN,PHC3,TRIM35-20,ZFML,LHX2A,CDADC1,LIMS1,RNF151
    retinoid X receptor binding PPARG,NR1H2,FUS,NR0B2,NRIP1,NR4A2,VDR,NSD1,NR1H4,MED25
    retinoic acid receptor activity NR1D4B,RARGA,RARB,RXRA,RARAA,RARAB,RARA,RARGB,ESRRG
    steroid hormone receptor activity NR2F1A,RXRAB,ESRRG,PPARAA,ESR2,THRAA,NR2F6A,NR4A1,RORB,NR2E3
    DNA binding MAFBA,ZBED5,EVE1,GLIS2,TERT,MLXIPL,HMGB3A,ZNF395,RPAP1,TCEB3
    RNA polymerase II regulatory region sequence-specific DNA binding PKNOX2,GATA5,NFKB1,FOXD3,AEBP1,GLIS1,SOHLH1,MNT,TAL1,TBX5
    protein binding GPN1,LETMD1,HOXA1,YY1A,HELT,MUC5B,PIK3CB,DCLRE1C,NAA11,SPC25

    Interacting Protein

    RARG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RARG here. Most of them are supplied by our site. Hope this information will be useful for your research of RARG.

    SORBS3;ZNF423;OIP5;MRPL12;IL24;LSR;RHPN2;ACY3;ZNF576;SPHK1;Sorbs3;MTMR6;FOXC1;myc_human_gene;tff1_human_gene;GREB1;ESR1;RARA

    Resources

    Research Area

    Transcription Regulators in VSMC
    Multiple Sclerosis and Myelin Related Molecules

    References

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