PTPN12
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Official Full Name
protein tyrosine phosphatase, non-receptor type 12 -
Overview
PTP-PEST is a ubiquitously expressed cytosolic protein tyrosine phosphatase with multiple proline-rich regions that appear to be the the docking sites for PTP-PEST binding partners or substrates (1). PTP-PEST regulates fibroblast adhesion, migration and c -
Synonyms
PTPN12;protein tyrosine phosphatase, non-receptor type 12;tyrosine-protein phosphatase non-receptor type 12;PTP PEST;PTPG1;protein-tyrosine phosphatase G1;PTP-PEST
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- HEK293
- Mammalian Cell
- E.coli
- Insect Cell
- Insect Cells
- HEK293T
- Myc&DDK
- His
- GST
- Non
- His&Fc
- His&GST
- His&T7
- His&Fc&Avi
Involved Pathway
PTPN12 involved in several pathways and played different roles in them. We selected most pathways PTPN12 participated on our site, such as EGFR1 Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTPN12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| EGFR1 Signaling Pathway | AP2A1,APPL2,ZNF259,RGS16,ERRFI1,USP6NL,EPS8,CEBPB,EPPK1,RGS5B |
Protein Function
PTPN12 has several biochemical functions, for example, SH3 domain binding,non-membrane spanning protein tyrosine phosphatase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTPN12 itself. We selected most functions PTPN12 had, and list some proteins which have the same functions with PTPN12. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| SH3 domain binding | SGIP1,FAM125A,SOS1,QKI2,SHANK2,WAS,ADAM12,HCLS1,PAK3,INPPL1 |
| protein binding | CD8B1,DTNBP1,CTDP1,IL7,HNRNPH2,IRX1,CSRP3,FAM109B,AGO1,ARMC9 |
| non-membrane spanning protein tyrosine phosphatase activity | PTPN18,PTPN4,ACP1,PTPN11,DUSP1,PTPN9 |
Interacting Protein
PTPN12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTPN12 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTPN12.
PDGFRB;PSTPIP1;EGFR;SHC1;WAS;BCAR1
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