PTK2B
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Official Full Name
protein tyrosine kinase 2 beta -
Overview
This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] -
Synonyms
PTK2B;protein tyrosine kinase 2 beta;PKB;PTK;CAKB;FAK2;PYK2;CADTK;FADK2;RAFTK;protein-tyrosine kinase 2-beta;FADK 2;CAK-beta;protein kinase B;focal adhesion kinase 2;cell adhesion kinase beta;proline-rich tyrosine kinase 2;calcium-dependent tyrosine kinase;PTK2B protein tyrosine kinase 2 beta;related adhesion focal tyrosine kinase;calcium-regulated non-receptor proline-rich tyrosine kinase
Recombinant Proteins
- Human
- Rat
- Mouse
- Sf9 Cells
- Insect Cells
- Mammalian Cells
- E.coli
- HEK293
- Sf21 Cells
- His
- GST
- GST&His
- Flag
- Non
- Avi&Fc&His
- DDK&Myc
Involved Pathway
PTK2B involved in several pathways and played different roles in them. We selected most pathways PTK2B participated on our site, such as Calcium signaling pathway,Chemokine signaling pathway,Phospholipase D signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTK2B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hepatitis B | NFATC3,SMAD4,EGR2,PIK3CG,PIK3R2,DDX58,IFNA6,STAT5B,PCNA,CREB3L2 |
| Natural killer cell mediated cytotoxicity | RAF1,SHC3,Casp3,NCR2,IFNA7,KIR2DL4,MICA,VAV2,SAMD3,PIK3R5 |
| GnRH signaling pathway | HRAS,GNAS,MMP14A,CALML3,PRKCBB,LHBETA1,MAP3K1,GRB2A,MAP2K2A,CALM2A |
| Calcium signaling pathway | ERBB4,P2RX2,TACR3A,CALM,ADORA2AB,OXTR,P2RX8,F2R,PPIFB,CALM3A |
| Leukocyte transendothelial migration | TXK,CLDN1,ITGB2,ITGAM,VASP,THY1,MYL9,MSN,NOX3,ARHGAP5 |
| Phospholipase D signaling pathway | PIK3R1,PTPN11,GAB2,PIP5K1C,MAPK3,TSC2,Adcy4,SYK,TSC1,PRKCA |
| Chemokine signaling pathway | STAT1,NFKBIA,GNAI1,CCL17,PLCB2,PIK3R2,NRAS,CCR6,CCL6,SOS1 |
Protein Function
PTK2B has several biochemical functions, for example, 3-phosphoinositide-dependent protein kinase binding,ATP binding,contributes_to NMDA glutamate receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PTK2B itself. We selected most functions PTK2B had, and list some proteins which have the same functions with PTK2B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to NMDA glutamate receptor activity | GRIN2A,GRIN3A,GRIN1 |
| non-membrane spanning protein tyrosine kinase activity | WEE1,CLK1,PRKCD,FES,TYK2,BLK,FGR,ABL2,ABL1,FER |
| signal transducer activity | AGTR1A,TAAR11,PTGER1A,V2RX1,HTR2CL1,SHISA5,GNAI2A,GNG13B,CELSR1,PLEKHB1 |
| protein tyrosine kinase activity | MET,MAP2K7,PTK7,RET,AXL,CLK3,ERBB3A,FGFR3,FGFR2,EK1 |
| protein complex binding | PEX26,PTCH1,PDX1,BCAP31,PPARA,CPS1,DAG1,LEPRE1,ADM2,PLK2 |
| receptor binding | CD58,BMP3,FRK,WNT7A,POU2F1,HAND2,CAT,FYNB,MSTN,IDUA |
| calmodulin-dependent protein kinase activity | CAMKK1,MAPKAPK5,CAMK1GB,CAMK2G1,CAMK2D,CAMK2G,MKNK2A,ITPKA,CAMK1GA,MYLK2 |
| ATP binding | NLRP5,ORC5,MYH11A,ABCB6,HSPA6,P2RX7,ACLY,MAST2,ABCB3L1,cka1 |
| protein binding | KIAA1530,CDK13,CCR5,CLTC,ZMYND10,GABARAPL2,DUSP19,CPEB3,Casp3,KLKB1 |
Interacting Protein
PTK2B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTK2B here. Most of them are supplied by our site. Hope this information will be useful for your research of PTK2B.
SRC;RHOU;FYN;MATK;MAP3K4;ERBB2;HSP90AB1;PDCD6IP;MYD88;yopM;q8ckf8_yerpe;q8ckm0_yerpe
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