PTI
-
Official Full Name
pancreatic trypsin inhibitor -
Overview
The protein encoded by this gene is a member of the serpin (serine proteinase inhibitor) superfamily, and;ovalbumin(ov)-serpin subfamily. It was originally discovered as a placental thrombin inhibitor. The mouse homolog was;found to be expressed in the hair cells of the inner ear. Mutations in this gene are associated with nonsyndromic;progressive hearing loss, suggesting that this serpin plays an important role in the inner ear in the protection;against leakage of lysosomal content during stress, and that loss of this protection results in cell death and;sensorineural hearing loss. Alternatively spliced transcript variants have been found for this gene. -
Synonyms
PTI;pancreatic trypsin inhibitor;Basic protease inhibitor;BPI;BPTI;aprotinin
Recombinant Proteins
- Bovine
- Bovine Lung
- E.coli
- Maize
- Non
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PTI-29B |
Active Native Bovine Aprotinin
|
Bovine Lung | Bovine | Non |
|
|
| PTI-50B | Recombinant Bovine Pancreatic Trypsin Inhibitor | E.coli | Bovine | Non |
|
|
| PTI-5357B | Recombinant Bovine Pancreatic Trypsin Inhibitor | Maize | Bovine | Non |
|
|
| PTI-152B | Active Recombinant Bovine PTI Protein | E.coli | Bovine | Non |
|
|
| PTI-1900B | Native Bovine Pancreatic Trypsin Inhibitor | Bovine Lung | Bovine | Non |
|
|
| PTI-603B | Native Bovine Pancreatic Trypsin Inhibitor | Bovine Lung | Bovine | Non |
|
|
| PTI-P063B | Native Bovine pancreatic trypsin inhibitor therapeutic protein (Aprotinin) | Bovine | Non | 58 Aa |
|
Involved Pathway
PTI involved in several pathways and played different roles in them. We selected most pathways PTI participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PTI were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
PTI has several biochemical functions, for example, potassium channel inhibitor activity,protein binding,serine-type endopeptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PTI itself. We selected most functions PTI had, and list some proteins which have the same functions with PTI. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | SKP1,ADORA2A,FOXO3B,KCTD6,BCL2L10,NEFL,CNKSR3,YTHDC1,IL4,LIN9 |
| potassium channel inhibitor activity | NEDD4L,KCNA5,RASA1,ENSA,KCNK2,CAV3 |
| serine-type endopeptidase inhibitor activity | COL6A3,ITIH2,CD109,SPINT2,SPINLW1,SERPIND1,SERPINI2,SPINT1A,ITIH6,SPINK3 |
Interacting Protein
PTI has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTI here. Most of them are supplied by our site. Hope this information will be useful for your research of PTI.
try1_bovin;polg_den26;q52v24_astlp;Prss2;tap_ornmo
Resources
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References
- Newcomer, BW; Toohey-Kurth, K; et al. Laboratory diagnosis and transmissibility of bovine viral diarrhea virus from a bull with a persistent testicular infection. VETERINARY MICROBIOLOGY 170:246-257(2014).
- Leonidova, A; Pierroz, V; et al. Photo-induced uncaging of a specific Re(I) organometallic complex in living cells. CHEMICAL SCIENCE 5:4044-4056(2014).
