PTH1R
-
Official Full Name
parathyroid hormone 1 receptor -
Overview
The protein encoded by this gene is a member of the G-protein coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in this receptor are known to be the cause of Jansens metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis. Two transcript variants encoding the same protein have been found for this gene. -
Synonyms
PTH1R;parathyroid hormone 1 receptor;parathyroid hormone receptor 1 , PTHR, PTHR1;parathyroid hormone/parathyroid hormone-related peptide receptor;PTH1 receptor;PTH/PTHr receptor;PTH/PTHrP type I receptor;parathyroid hormone receptor 1;seven trans
Recombinant Proteins
- Rat
- Human
- Mouse
- Chicken
- Pongo Abelii
- Bovine
- Mus musculus
- Didelphis virginiana (North American opossum) (Didelphis marsupialis virginiana)
- Dog
- Sus scrofa (Pig)
- HEK293
- Mammalian Cells
- E.coli
- Human Cells
- His
- Non
- His&Flag
- His&Fc&Avi
Involved Pathway
PTH1R involved in several pathways and played different roles in them. We selected most pathways PTH1R participated on our site, such as Neuroactive ligand-receptor interaction,Endocrine and other factor-regulated calcium reabsorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTH1R were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endocrine and other factor-regulated calcium reabsorption | ESR1,FXYD2,DNM3,ATP1B2,PLCB1,ATP1A3,CALB1,PRKACG,VDR,ATP1A4 |
| Neuroactive ligand-receptor interaction | CHRM2A,CNR1,SCTR,GLRA3,AVPR1B,RXFP2,F2RL3,PTGER3,CHRNA2,TAAR10D |
Protein Function
PTH1R has several biochemical functions, for example, parathyroid hormone receptor activity,peptide hormone binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTH1R itself. We selected most functions PTH1R had, and list some proteins which have the same functions with PTH1R. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | PINX1,PSMB8,SMO,STIM1,SEC22B,CTRC,SH2D4A,GNAI3,TSGA10,PTGES2 |
| protein self-association | TMEM43,ZKSCAN17,PABPN1,MDH2,CCDC88C,BCL10,ABCD3,L1CAM,VAMP2,PCSK9 |
| peptide hormone binding | MC3R,GHR,MC4R,SLC40A1,HCRTR2,GHRHR,CRHR2,ECE1,NPR1,RXFP2 |
| parathyroid hormone receptor activity | PTH1RB,PTH2R,PTH1RA |
Interacting Protein
PTH1R has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTH1R here. Most of them are supplied by our site. Hope this information will be useful for your research of PTH1R.
CTNNB1;YWHAH;CALM1;wzzE
Resources
Research Area
Renal MarkersOsteoclast Markers
Peptide Hormone G Protein-Coupled Receptors
Osteoblast and Osteoclast Markers
Related Services
Related Products
References
- Charest-Morin, X; Fortin, JP; et al. A tagged parathyroid hormone derivative as a carrier of antibody cargoes transported by the G protein coupled PTH1 receptor. PEPTIDES 60:71-79(2014).
- Hohenstein, A; Hebell, M; et al. Development and validation of a novel cell-based assay for potency determination of human parathyroid hormone (PTH). JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 98:345-350(2014).
