PTGES2
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Official Full Name
prostaglandin E synthase 2 -
Overview
The protein encoded by this gene is a membrane-associated prostaglandin E synthase, which catalyzes the conversion of prostaglandin H2 to prostaglandin E2. This protein also has been shown to activate the transcription regulated by a gamma-interferon-activated transcription element (GATE). Multiple transcript variants have been found for this gene. -
Synonyms
PTGES2;prostaglandin E synthase 2;C9orf15, chromosome 9 open reading frame 15;FLJ14038;C9orf15;Gamma interferon activated transcriptional element binding factor 1;GATE binding factor 1;GBF1;Membrane associated prostaglandin E synthase 2;MGC11289;Microsomal prostaglandin E synthase 2;mPGES 2;mPGES-2;PGES2;PGES2_HUMAN;Prostaglandin E synthase 2 truncated form;PTGES 2;OTTHUMP00000022231;OTTHUMP00000022232;OTTHUMP00000215363;GATE-binding factor 1;microsomal prostaglandin E synthase-2;membrane-associated prostaglandin E synthase 2;gamma-interferon-activated
Recombinant Proteins
- Human
- Mouse
- Cynomolgus
- zebrafish
- E.coli
- Mammalian Cell
- HEK293
- E.coli expression system
- GST
- His
- His&T7
- Non
- His&Fc&Avi
Involved Pathway
PTGES2 involved in several pathways and played different roles in them. We selected most pathways PTGES2 participated on our site, such as Arachidonic acid metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTGES2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Arachidonic acid metabolism | CYP2C70,CYP1A1,ALOX5B.2,CBR2,GPX6,ALOX15B,CYP2E1,ALOX5A,CYP2P7,PLA2G12A |
| Metabolic pathways | PIGX,Cel,GGT5,ATP6V1C2,CYP21A1,AK2,ALPL,LYCAT,SDSL,PANK1B |
Protein Function
PTGES2 has several biochemical functions, for example, DNA binding,electron carrier activity,glutathione binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTGES2 itself. We selected most functions PTGES2 had, and list some proteins which have the same functions with PTGES2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein disulfide oxidoreductase activity | CCS,GSTK1,GLRX2,CHCHD4,TXN,TXN2,DNAJC10,GRX2,ERO1LB,PTGESL |
| prostaglandin-E synthase activity | PTGES3,PTGESL,PTGES |
| glutathione binding | LTC4S,MGST1,GSTM1,GSTM2,PTGESL,GSTM4,GPX1,LANCL1,GSTM7,GSTM3 |
| electron carrier activity | SDHC,NQO2,ACAD9,ACAD8,NOX4,DERL3,SDHD,COX7A2A,ALDH4A1,ETFB |
| lyase activity | ENO1A,TYW1B,GUCY2E,CRY5,GC3,CAR7,GLDC,HMGB1,NPR1A,URAD |
| protein binding | BDKRB2,HSPA1B,FOXG1,GPR128,GABARAPL1,DHDDS,WFIKKN1,KIF5A,HOPX,SPAG8 |
| heme binding | BACH1,CYP8B2,CYP39A1,CYP2X10.2,GUCY1A3,CYP2V1,CYP21A2,CYP2K18,PGRMC2,FECH |
| DNA binding | THAP2,ZNF789,GM14479,NFYC,THRAA,ZBTB20,MYPOP,ZZZ3,MYCA,DICER1 |
Interacting Protein
PTGES2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTGES2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTGES2.
C1orf189;HTT;EXOSC10;uvrB;MYC;1C;H2AFX
Resources
Research Area
NeuroinflammationNeurotransmitter Associated Enzymes
Prostaglandin Synthases
MDSC Cytokines and Growth Factors
Related Services
Related Products
References
