PTDSS2
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Official Full Name
phosphatidylserine synthase 2 -
Overview
Phosphatidylserine (PS) accounts for 5 to 10% of cell membrane phospholipids. In addition to its role as a structural;component, PS is involved in cell signaling, blood coagulation, and apoptosis. PS is synthesized by a;calcium-dependent base-exchange reaction catalyzed by PS synthases (EC 2.7.8.8), like PTDSS2, that exchange L-serine;for the polar head group of phosphatidylcholine (PC) or phosphatidylethanolamine (PE) (Sturbois-Balcerzak et al., 2001;(PubMed 11084049)). -
Synonyms
PTDSS2;phosphatidylserine synthase 2;PSS2;PSS-2;ptdSer synthase 2;serine-exchange enzyme II;FLJ46373
Recombinant Proteins
- Mouse
- Chicken
- Rat
- Human
- Cricetulus griseus
- Mus musculus
- Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
- zebrafish
- Mammalian Cells
- HEK293
- E.coli
- His
- His&Fc&Avi
Involved Pathway
PTDSS2 involved in several pathways and played different roles in them. We selected most pathways PTDSS2 participated on our site, such as Glycerophospholipid metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTDSS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glycerophospholipid metabolism | PCYT1AA,PLA2G15,ADPRM,PLA2G4F,TAZ,PPAP2D,PCYT2,GPD2,LPCAT3,CEPT1 |
| Metabolic pathways | COX5A,MTHFR,POLR2K,NADK2,LTA4H,PTGS2,CBR2,ST3GAL5,ALPI,NDUFV2 |
Protein Function
PTDSS2 has several biochemical functions, for example, CDP-diacylglycerol-serine O-phosphatidyltransferase activity,transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PTDSS2 itself. We selected most functions PTDSS2 had, and list some proteins which have the same functions with PTDSS2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transferase activity | TAOK1,MGST1.1,SULT3ST3,PYGMB,CAMKK1A,SULT1ST3,ST3GAL3B,GBGT1L1,PAK2A,POMGNT2 |
Interacting Protein
PTDSS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTDSS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTDSS2.
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References
- Lee, S; Uchida, Y; et al. Impaired retrograde membrane traffic through endosomes in a mutant CHO cell defective in phosphatidylserine synthesis. GENES TO CELLS 17:728-736(2012).
- Dissanayake, DRA; Wijewardana, TG; et al. Potential use of a liposome-encapsulated mixture of lipopolysaccharide core types (R1, R2, R3 and R4) of Escherichia coli in controlling colisepticaemia in chickens. JOURNAL OF MEDICAL MICROBIOLOGY 59:100-107(2010).
