PSPH
-
Official Full Name
phosphoserine phosphatase -
Overview
The protein encoded by this gene belongs to a subfamily of the phosphotransferases. This encoded enzyme is responsible for the third and last step in L-serine formation. It catalyzes magnesium-dependent hydrolysis of L-phosphoserine and is also involved in an exchange reaction between L-serine and L-phosphoserine. Deficiency of this protein is thought to be linked to Williams syndrome. -
Synonyms
PSPH;phosphoserine phosphatase;PSP;EC 3.1.3.3;L 3 phosphoserine phosphatase;O phosphoserine phosphohydrolase;Phosphoserine phosphatase deficiency, included;PSPase;OTTHUMP00000159738;OTTHUMP00000209319;OTTHUMP00000209324;OTTHUMP00000209327;L-3-phosphoserine phosphatase;O-phosphoserine phosphohydrolase;PSPHD
Recombinant Proteins
- Mouse
- Human
- Zebrafish
- Chicken
- Rat
- Mammalian Cell
- E.coli
- HEK293T
- HEK293
- E. coli
- His
- Non
- Myc&DDK
- GST
- His&Fc&Avi
Involved Pathway
PSPH involved in several pathways and played different roles in them. We selected most pathways PSPH participated on our site, such as Glycine, serine and threonine metabolism,Metabolic pathways,Carbon metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PSPH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Carbon metabolism | AGXTB,ACSS2L,PDHA1,ANI_1_2390104,DLDH,SDHA,PC,CAT,PDHA2,ME3 |
| Metabolic pathways | NNMT,PFKL,HADH,ITPA,TKT,PPAP2B,NDUFB4,GALNT10,SPTLC3,ST6GALNAC5 |
| Biosynthesis of amino acids | PFKL,GLULA,CBSB,GOT2B,MAT1A,ENO2,CPS1,MAT2B,MAT2AA,PGK1 |
| Glycine, serine and threonine metabolism | DAO.2,SHMT2,THA1,BPGM,DAO,SDSL,GLYCTK,DAO.1,ALAS2,SDS |
Protein Function
PSPH has several biochemical functions, for example, calcium ion binding,magnesium ion binding,phosphoserine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PSPH itself. We selected most functions PSPH had, and list some proteins which have the same functions with PSPH. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| phosphoserine phosphatase activity | PDXP,DUSP26 |
| calcium ion binding | NECAB2,NOTCH3,EMR3,RCN1,THBS4A,MYLPF,RYR3,ATP2A1,PCDH2AB11,PGS1 |
| magnesium ion binding | PKMA,RPS6KA6,ALPP,MAP3K6,PPM1AA,NIM1K,FOXK2,TSSK1,PGM5,NT5C3L |
| protein homodimerization activity | ATIC,PVALB,TREX2,SIAH1A,SRM,TKT,CER1,CEBPA,PRPS1,TESCA |
Interacting Protein
PSPH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PSPH here. Most of them are supplied by our site. Hope this information will be useful for your research of PSPH.
q65zq1_human;PTP4A3;TXN;CAP2;RPS9;RPS28;ERH;CIRBP;PRPSAP1;TNFRSF14;PRMT1;MOB1A;ASF1B;IGF2BP1;STYXL1;ATXN1
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