PSMD4
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Official Full Name
proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 -
Overview
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. Pseudogenes have been identified on chromosomes 10 and 21. -
Synonyms
PSMD4;proteasome (prosome, macropain) 26S subunit, non-ATPase, 4;26S proteasome non-ATPase regulatory subunit 4;AF;AF 1;Rpn10;S5A;angiocidin;RPN10 homolog;antisecretory factor 1;S5a/antisecretory factor protein;multiubiquitin chain-binding prot
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Chicken
- E.coli
- Mammalian Cell
- HEK293
- E. coli
- HEK293T
- His
- GST
- His&GST
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
PSMD4 involved in several pathways and played different roles in them. We selected most pathways PSMD4 participated on our site, such as Proteasome,Epstein-Barr virus infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with PSMD4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Epstein-Barr virus infection | PSMD1,EIF2AK1,TP53,POLR2K,IKBKG,TRAF5,TRP53,NFKBIE,MAPK10,AKT1 |
| Proteasome | PSMB4,PSMC3,IFNG1-2,PSMD11B,PSMB9B,PSMB11B,PSMD4B,PSMA6B,PSMB10,PSME2 |
Protein Function
PSMD4 has several biochemical functions, for example, identical protein binding,poly(A) RNA binding,polyubiquitin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PSMD4 itself. We selected most functions PSMD4 had, and list some proteins which have the same functions with PSMD4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | RICTOR,MAP3K7IP3,C1orf105,DPP3,ILF2,PPIL3,RPS16,STX5,KCNJ6,XPO7 |
| polyubiquitin binding | EPS15,AGL,DZIP3,THRSP,FAM175A,TNIP3,RAD23A,SHARPIN,UBQLN4,PSMD4B |
| transcription factor binding | KAT2A,DDX3X,NKX2,HMGB2,TNFRSF10A,FOXO4,ARID5A,TAF7,PSMD10,DIP2BA |
| identical protein binding | PHYKPL,CLDN8,APOE,INS2,RAF1,SHANK3,TYSND1,NONO,NQO1,MDM2 |
| poly(A) RNA binding | DIDO1,RPS13,EEF1A1,RC3H2,HIST1H4C,NOP58,TDRD3,TRNAU1AP,SNTB2,RRP8 |
Interacting Protein
PSMD4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PSMD4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PSMD4.
UBC;RAD23B
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