PRRX1
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Official Full Name
paired related homeobox 1 -
Overview
The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription co-activator, enhancing the DNA-binding activity of serum response factor, a protein required for the induction of genes by growth and differentiation factors. The protein regulates muscle creatine kinase, indicating a role in the establishment of diverse mesodermal muscle types. Alternative splicing yields two isoforms that differ in abundance and expression patterns. -
Synonyms
PRRX1;paired related homeobox 1;paired mesoderm homeo box 1 , PMX1;paired mesoderm homeobox protein 1;PHOX1;AGOTC;Homeobox protein PHOX1;Paired mesoderm homeo box 1;Paired mesoderm homeobox 1;paired mesoderm homeobox 1 isoform pmx-1b;Paired related homeobox protein 1;Paired-related homeobox protein 1;PHOX 1;PHOX1 1, 2;PMX 1;PMX1;PRRX 1;PRRX1_HUMAN;PRX 1;PRX-1;PRX1
Recombinant Proteins
- Chicken
- Human
- Rat
- Mouse
- Mammalian Cell
- E.coli
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- HEK293T
- His
- Non
- His&Fc&Avi
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PRRX1-1747C | Recombinant Chicken PRRX1 | Mammalian Cell | Chicken | His |
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| PRRX1-285H | Recombinant Human paired related homeobox 1, His-tagged | E.coli | Human | His | 1-217 a.a. |
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| PRRX1-30707TH | Recombinant Human PRRX1 | Wheat Germ | Human | Non | 90 amino acids |
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| PRRX1-31000TH | Recombinant Human PRRX1 | Wheat Germ | Human | Non | 217 amino acids |
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| PRRX1-317H | Recombinant Human PRRX1 | Mammalian Cell | Human | His |
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| PRRX1-4735R | Recombinant Rat PRRX1 Protein | Mammalian Cell | Rat | His |
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| PRRX1-5096C | Recombinant Chicken PRRX1 | Mammalian Cell | Chicken | His |
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| PRRX1-2807HCL | Recombinant Human PRRX1 293 Cell Lysate | HEK293 | Human | Non |
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| PRRX1-2787H | Recombinant Human PRRX1 protein(11-80 aa), C-His-tagged | E.coli | Human | His | 11-80 aa |
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| PRRX1-3924H | Recombinant Human PRRX1 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| PRRX1-3924H-B | Recombinant Human PRRX1 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| PRRX1-427HF | Recombinant Full Length Human PRRX1 Protein | In Vitro Cell Free System | Human | Full L. 217 amino acids |
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| PRRX1-4394R | Recombinant Rat PRRX1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| PRRX1-4394R-B | Recombinant Rat PRRX1 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| Prrx1-5162M | Recombinant Mouse Prrx1 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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Involved Pathway
PRRX1 involved in several pathways and played different roles in them. We selected most pathways PRRX1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PRRX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
PRRX1 has several biochemical functions, for example, HMG box domain binding,RNA polymerase II transcription coactivator activity,sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRRX1 itself. We selected most functions PRRX1 had, and list some proteins which have the same functions with PRRX1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| sequence-specific DNA binding | NKX6.3,LHX8,HOXA3,NKX2.4B,ZFP423,GATA1,NEUROG2,FOXQ2,HOXC5,GLI2 |
| HMG box domain binding | EGR2,POU3F3,HHEX,CEBPA,UTF1,HOXC4,DLX5,JUN,SP1,OLIG2 |
| transcription coactivator activity | BRD7,MNT,CITED4,NR5A1,LPIN3,TDRD3,RIPK3,TADA2A,BCL10,MAML1 |
| RNA polymerase II transcription coactivator activity | POU3F2,RERE,SOX4,SMARCA4,POU1F1,PITX2,SOX11,CITED4,ISL1,MEF2A |
Interacting Protein
PRRX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRRX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRRX1.
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References
- Nanez, A; Ramos, IN; et al. A Mutant Ahr Allele Protects the Embryonic Kidney from Hydrocarbon-Induced Deficits in Fetal Programming. ENVIRONMENTAL HEALTH PERSPECTIVES 119:1745-1753(2011).
- Perco, P; Blaha, P; et al. Molecular signature of mice T lymphocytes following tolerance induction by allogeneic BMT and CD40-CD40L costimulation blockade. TRANSPLANT INTERNATIONAL 19:146-157(2006).
