PROK1

  • Official Full Name

    prokineticin 1

  • Overview

    The protein encoded by this gene induces proliferation, migration, and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. It has little or no effect on a variety of other endothelial and non-endothelial cell types. Its expression is restricted to the steroidogenic glands (ovary, testis, adrenal, and placenta), is induced by hypoxia, and often complementary to the expression of vascular endothelial growth factor (VEGF), suggesting that these molecules function in a coordinated manner.

  • Synonyms

    EG-VEGF;Endocrine-gland-derived vascular endothelial growth factor;Mambakine;PROK1;PROK1_HUMAN;Prokineticin-1;prokineticin 1;PK1;PRK1;EGVEGF

Recombinant Proteins

  • Mouse
  • Human
  • Rhesus macaque
  • Rat
  • Zebrafish
  • Mammalian cells
  • E.coli
  • Mammalian Cell
  • Insect Cells
  • Insect Cell
  • HEK293
  • Non
  • His
  • His&GST
  • Fc
  • His&Fc&Avi
  • His&SUMO
Cat.# Product name Source (Host) Species Tag Protein Length Price
Prok1-396M Active Recombinant Mouse Prokineticin 1 Mammalian cells Mouse Non 20-105 a.a.
PROK1-13430M Recombinant Mouse PROK1 protein E.coli Mouse Non 86
PROK1-335H Recombinant Human Prokineticin 1 Mammalian cells Human Non
PROK1-3618R Recombinant Rhesus monkey PROK1 Protein, His-tagged Mammalian Cell Rhesus macaque His
PROK1-43H Recombinant Human PROK1 protein E.coli Human Non 86
PROK1-4712R Recombinant Rat PROK1 Protein Mammalian Cell Rat His
PROK1-592H Recombinant Human PROK1 protein, His & GST-tagged E.coli Human His&GST Met1~Phe105
PROK1-6036Z Recombinant Zebrafish PROK1 Mammalian Cell Zebrafish His
PROK1-7517H Recombinant Human PROK1 protein, His-tagged Insect Cells Human His Met1-Phe105
PROK1-8458H Active Recombinant Human PROK1 Mammalian cells Human Non
PROK1-001HCL Recombinant Human PROK1 cell lysate Insect Cell Human Non
Prok1-078MG Active GMP Recombinant Mouse Prok1 protein, Fc-tagged HEK293 Mouse Fc DNA sequence encoding Mouse EG-VEGF(NCBI: NP_001037847.1) was expressed with Fc tag at the C-terminal.
Prok1-10610M Recombinant Mouse Prok1 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
Prok1-10610M-B Recombinant Mouse Prok1 Protein Pre-coupled Magnetic Beads HEK293 Mouse
Prok1-1200M Recombinant Mouse Prok1 Protein, His&SUMO-tagged E.coli Mouse His&SUMO Met1-Phe105
PROK1-230H Recombinant Human PROK1 Protein E.coli Human
PROK1-3436R Recombinant Rhesus Macaque PROK1 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
PROK1-3436R-B Recombinant Rhesus Macaque PROK1 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
PROK1-4371R Recombinant Rat PROK1 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
PROK1-4371R-B Recombinant Rat PROK1 Protein Pre-coupled Magnetic Beads HEK293 Rat
PROK1-4476H Recombinant Human PROK1 Protein, His (Fc)-Avi-tagged HEK293 Human His&Fc&Avi
PROK1-4476H-B Recombinant Human PROK1 Protein Pre-coupled Magnetic Beads HEK293 Human

    Involved Pathway

    PROK1 involved in several pathways and played different roles in them. We selected most pathways PROK1 participated on our site, such as Class A/1 (Rhodopsin-like receptors),G alpha (q) signalling events,GPCR downstream signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with PROK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Signaling by GPCR INSL3,ANXA1B,NMB,ARHGEF3,ARHGAP4,NTS,GNA13B,DCLRE1B,OXTRL,ARHGEF16
    Gastrin-CREB signalling pathway via PKC and MAPK EDN3,QRFP,GCGB,RGS18,GCGA,PROKR2,OPN4.1,GPR68,OPN4A,LPAR2B
    G alpha (q) signalling events ANXA1A,GPRC6A,GRP,TRH,AGT,TAC1,NPS,TRPC7,EDNRB,OPN4
    Peptide ligand-binding receptors NPB,NTS,PROKR1A,CXCL11.8,QRFP,MLN,RLN3A,SSTR4,HCRT,TAC3
    GPCR ligand binding APLNR,CXCL13,HCAR1-2,CCL35.1,GNB5B,ADORA2B,ANXA1,DRD5,CRHB,RLN3A
    Class A/1 (Rhodopsin-like receptors) MLN,LTB4R,CYSLTR1,AGTR1,EDNRAB,NMBA,EDN2,RXFP2,ADRA2C,ADRA1B
    Signal Transduction ROR1,RAMP3,NF2A,NPB,CXCL11.8,GPR177,USP2,ARHGAP18,OPN4,TAGAPB
    GPCR downstream signaling CCL35.1,CXCL13,HEBP1,SSTR2,NPB,ADRA2A,ADORA3,OXGR1A.2,ANXA1,SST

    Protein Function

    PROK1 has several biochemical functions, for example, G-protein coupled receptor binding,growth factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PROK1 itself. We selected most functions PROK1 had, and list some proteins which have the same functions with PROK1. You can find most of the proteins on our site.

    Function Related Protein
    G-protein coupled receptor binding GNA11A,RSPO2,GNA15.4,ADORA1,GNA14,GNA11B,GNAV1,PICK1,FCN1,GNA12A
    growth factor activity GDF15,PDGFAA,BMP2,GPI1,LFT1,PPBP,SPAW,FGF6B,CLEC11A,PTN

    Interacting Protein

    PROK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PROK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PROK1.

    Resources

    Research Area

    Other Cytokines & Receptors

    References

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