PRKRA

  • Official Full Name

    protein kinase, interferon-inducible double stranded RNA dependent activator
  • Overview

    This gene encodes a protein kinase activated by double-stranded RNA which mediates the effects of interferon in response to viral infection. Mutations in this gene have been associated with dystonia. Alternative splicing results in multiple transcript variants.
  • Synonyms

    PRKRA;protein kinase, interferon-inducible double stranded RNA dependent activator;interferon-inducible double stranded RNA-dependent protein kinase activator A;DYT16;HSD14;PACT;protein activator of the interferon induced protein kinase;RAX;PKR-as

Recombinant Proteins

  • Human
  • Rhesus macaque
  • Rat
  • Zebrafish
  • Bovine
  • Mouse
  • E.coli
  • Mammalian Cell
  • HEK293
  • Mammalian cells
  • HEK293T
  • GST
  • His
  • Non
  • Flag
  • His&Fc&Avi
  • His&Myc
  • Myc&DDK
Cat.# Product name Source (Host) Species Tag Protein Length Price
PRKRA-1960H Recombinant Human PRKRA, GST-tagged E.coli Human GST 1-313aa
PRKRA-3609R Recombinant Rhesus monkey PRKRA Protein, His-tagged Mammalian Cell Rhesus macaque His
PRKRA-4686R Recombinant Rat PRKRA Protein Mammalian Cell Rat His
PRKRA-5514Z Recombinant Zebrafish PRKRA Mammalian Cell Zebrafish His
PRKRA-2848HCL Recombinant Human PRKRA 293 Cell Lysate HEK293 Human Non
PRKRA-1175HFL Recombinant Full Length Human PRKRA Protein, C-Flag-tagged Mammalian cells Human Flag Full L.
PRKRA-1769H Recombinant Human PRKRA Protein, His (Fc)-Avi-tagged HEK293 Human His&Fc&Avi
PRKRA-1769H-B Recombinant Human PRKRA Protein Pre-coupled Magnetic Beads HEK293 Human
PRKRA-2502B Recombinant Bovine PRKRA Protein (1-313 aa), His-Myc-tagged E.coli Bovine His&Myc 1-313 aa
PRKRA-3427R Recombinant Rhesus Macaque PRKRA Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
PRKRA-3427R-B Recombinant Rhesus Macaque PRKRA Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
PRKRA-4345R Recombinant Rat PRKRA Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
PRKRA-4345R-B Recombinant Rat PRKRA Protein Pre-coupled Magnetic Beads HEK293 Rat
Prkra-5127M Recombinant Mouse Prkra Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
PRKRA-654H Recombinant Human PRKRA Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK

    Involved Pathway

    PRKRA involved in several pathways and played different roles in them. We selected most pathways PRKRA participated on our site, such as Aflatoxin B1 metabolism,Aflatoxin activation and detoxification,Biological oxidations, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRKRA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Aflatoxin B1 metabolism CYP3A4,FAM84B,CYP1A2,CYP2A13
    Aflatoxin activation and detoxification CYP3C4,ACY3,GGT6,GGTLC1,CYP3A5,ACY3.2,DPEP1,CYP3A4,FAM84B,CYP1A2
    Metabolism of xenobiotics by cytochrome P450 GSTK1,ADH2-1,AKR1C4,CYP2F1,CYP2S1,AKR1C2,ADH2-2
    Metabolism SLC26A1,ACMSD,SLC25A20,GNG13A,COX6A1,CYP17A1,ALOX5B.2,INSIG1,ACSM1,DAO1
    Biological oxidations GLYATL1,ADH5,CYP3A4,CYP4F12,CYP2A6,UGT1B2,CYP1B1,CYP2AD2,AS3MT,AKR1A1
    metapathway biotransformation CHST4,CHST9,NAT9,SULT1C4,SULT1B1,CYP4V2,CHST8,CYP2W1,SULT1C2,HS3ST4

    Protein Function

    PRKRA has several biochemical functions, for example, alditol:NADP+ 1-oxidoreductase activity,electron carrier activity,phenanthrene-9,10-epoxide hydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRKRA itself. We selected most functions PRKRA had, and list some proteins which have the same functions with PRKRA. You can find most of the proteins on our site.

    Function Related Protein
    phenanthrene-9,10-epoxide hydrolase activity AKR7A5,AKR7A2
    alditol:NADP+ 1-oxidoreductase activity AKR7A5,AKR1A1,AKR1C2,AKR1B1,AKR1C21,AKR1C3,ADH4,AKR7A2,AKR1B8,AKR1B7
    electron carrier activity COX5A,AOC2,DHDH,QDPR,TXNRD3,NDUFS2,FDX1L,FDX1,PHGDH,SH3BGRL3

    Interacting Protein

    PRKRA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRKRA here. Most of them are supplied by our site. Hope this information will be useful for your research of PRKRA.

    TARBP2;LYAR;ZMAT3;NS;EIF2AK2

    Resources

    References

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