PRKCI
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Official Full Name
protein kinase C, iota -
Overview
This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X. -
Synonyms
PRKCI;protein kinase C, iota;DXS1179E;protein kinase C iota type;PKCI;PRKC-lambda/iota;aPKC-lambda/iota;atypical protein kinase C-lambda/iota;nPKC-iota;MGC26534
Recombinant Proteins
- Human
- Chicken
- Rat
- Zebrafish
- Mouse
- E.coli
- Insect Cells
- HEK293
- Sf9 Cells
- Mammalian Cells
- Sf21 Cells
- GST
- His
- Non
- His&T7
- Myc&DDK
- His&Fc&Avi
Involved Pathway
PRKCI involved in several pathways and played different roles in them. We selected most pathways PRKCI participated on our site, such as Rap signaling pathway,Endocytosis,Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRKCI were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hippo signaling pathway | TEAD1,FZD8,TGFB1,TEAD2,YAP1,SNAI2,FRMD6,SAV1,PPP2R2C,WWTR1 |
| Rap signaling pathway | ITGB1,VAV2,FGF14,INSR,PDGFD,MLLT4,GNAI2,BCAR1,KLK1B4,MRAS |
| Endocytosis | SH3GL3A,CLTCB,WIPF2,CYTH1A,GIT2,SNX32,SH3GLB1,IL2RGA,GIT1,PSD |
| Platelet activation | ARHGAP35,PRKG1,PLA2G4A,GNAI3,NOS3,MAPK3,MYL12A,PPP1R12A,PIK3CA,PRKG2 |
| Tight junction | PARD6GB,RHOA,MAGI1,CLDN11B,PRKCBB,CLDNJ,SPTAN1,MYHC4,RRAS,TJP2 |
| Insulin signaling pathway | EIF4E2,PDE3B,PKLR,CALM3B,INSRB,CALM2A,EIF4E2RS1,AKT3A,BAD,IRS2 |
Protein Function
PRKCI has several biochemical functions, for example, ATP binding,metal ion binding,phospholipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRKCI itself. We selected most functions PRKCI had, and list some proteins which have the same functions with PRKCI. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | MYH11,VARS2,NUBPL,SMC2,BRIP1,DDX17,PRKCBB,MAPK9,BMPR2A,DNAJA3B |
| protein kinase activity | CDK7,CLK2B,VSIG8B,PRKCA,RPS6KA3,ROCK1,SNRKA,TESK2,RIPK1L,FASTKD2 |
| protein domain specific binding | AKAP1,TFDP1,MITD1,TH,NEDD4,BHLHE40,CASKIN1,MRPS31,PRKAR2B,PLG |
| metal ion binding | KSR1,OSR2,GLI2A,DNAJA3,ATP2B1A,ZNF358,ZFP90,LIMK1A,TRIM35-35,ZNF764 |
| protein binding | TNFRSF10A,COL1A2,EWSR1A,AIRE,ZNF580,TRIM41,YWHAQ,PIDD1,CD2BP2,GTF2IRD2 |
| protein kinase C activity | PRKD2,PRKCE,PRKCA,PKN3,PRKCZ,PRKD1,PRKCB,PRKCG,PRKCDA,PRKCHA |
| phospholipid binding | SPTBN2,NUP35,SNCA,APOEB,NR5A1,SHC1,ABCA1,SYTL4,GLTPD1,GRK5 |
| protein serine/threonine kinase activity | DCKL1B,CSNK1E,PAK6,SPEG,PRKCHA,AURKB,STK17B,CAMK2B1,MAP2K3,PRKCBA |
Interacting Protein
PRKCI has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRKCI here. Most of them are supplied by our site. Hope this information will be useful for your research of PRKCI.
PARD6A;PARD6B
Resources
Research Area
Intracellular Kinases in the Akt PathwayPKC Isoforms
Wnt Intracellular Signaling
Intracellular Signaling Molecules in Angiogenesis
PKC Family
Related Services
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References
