PRKAR1A
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Official Full Name
protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) -
Overview
cAMP-dependent protein kinase type I-alpha regulatory subunit (PRKAR1A) is the regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. PRKAR1A is also known as tissue-specific extinguisher 1 (TSE1); PRKAR1A was found -
Synonyms
PRKAR1A;protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1);PRKAR1, TSE1;cAMP-dependent protein kinase type I-alpha regulatory subunit;tissue-specific extinguisher 1;protein kinase A type 1a regulatory subunit
Recombinant Proteins
- Human
- Chicken
- Rat
- Bovine
- Mouse
- HEK293
- E.coli
- Mammalian Cells
- Human Cells
- Sf9 Cells
- Insect Cells
- Myc&DDK
- GST
- His
- Non
- Flag
- His&Fc&Avi
Involved Pathway
PRKAR1A involved in several pathways and played different roles in them. We selected most pathways PRKAR1A participated on our site, such as Apoptosis,Insulin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRKAR1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Insulin signaling pathway | SHC3,PPP1R3D,CALM1A,CALM3,PPP1CA,PRKAG1,CBLB,PHKA1,LIPE,PIK3R3 |
| Apoptosis | IKBKB,DBNLA,IL1B,HMGB2A,CASP4,BCL2,CYCS,BCL2L11,MYC,IRF4A |
Protein Function
PRKAR1A has several biochemical functions, for example, cAMP binding,cAMP-dependent protein kinase inhibitor activity,cAMP-dependent protein kinase regulator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRKAR1A itself. We selected most functions PRKAR1A had, and list some proteins which have the same functions with PRKAR1A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein kinase A catalytic subunit binding | PRKAR2B,SOX9,PRKAR2A,GSK3A,KCNQ1,PJA2,RYR2,GSK3B,CSK,PRKAR1B |
| cAMP binding | CNMPD1,RAPGEF4,PDE11A,PRKAR2B,CNGA2,PDE3A,POPDC2,PRKAR2A,PDE10A,PDE4D |
| ubiquitin protein ligase binding | POU5F1,ANAPC2,PRKAR2A,IKBKG,ATP6V0C,SNX9,CALR,UBE2Z,VCP,FHIT |
| cAMP-dependent protein kinase inhibitor activity | PKIA,PRKAR2A,PRKAG2,PRKAR1B,PRKAR2B,PKIB,PKIG |
| protein binding | C19orf10,TIGIT,NIP7,FARSA,CLIC5,TUB,PKM,GLS,VEZT,MAPK7 |
| cAMP-dependent protein kinase regulator activity | PRKAR2AB,CXCL10,PRKAG2,PRKAR2AA,PRKAR1B,PRKAG1,PRKAR1AB,PRKAR2B,PRKAR2A,PRKAR1AA |
Interacting Protein
PRKAR1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRKAR1A here. Most of them are supplied by our site. Hope this information will be useful for your research of PRKAR1A.
PRKACA;p03259-2;PLEKHF2;3',5'-cyclic amp;GABARAPL1;RFC2
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References
- Carney, JA; Libe, R; et al. Primary Pigmented Nodular Adrenocortical Disease The Original 4 Cases Revisited After 30 Years for Follow-up, New Investigations, and Molecular Genetic Findings. AMERICAN JOURNAL OF SURGICAL PATHOLOGY 38:1266-1273(2014).
- Torres-Mora, J; Dry, S; et al. Malignant Melanotic Schwannian Tumor A Clinicopathologic, Immunohistochemical, and Gene Expression Profiling Study of 40 Cases, With a Proposal for the Reclassification of "Melanotic Schwannoma". AMERICAN JOURNAL OF SURGICAL PATHOLOGY 38:94-105(2014).
