PRDX6
-
Official Full Name
peroxiredoxin 6 -
Overview
The protein encoded by this gene is a member of the thiol-specific antioxidant protein family. This protein is a bifunctional enzyme with two distinct active sites. It is involved in redox regulation of the cell; it can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. It may play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury. [provided by RefSeq, Jul 2008] -
Synonyms
PRDX6;peroxiredoxin 6;PRX;p29;AOP2;1-Cys;NSGPx;aiPLA2;HEL-S-128m;peroxiredoxin-6;1-Cys PRX;24 kDa protein;1-Cys peroxiredoxin;antioxidant protein 2;liver 2D page spot 40;red blood cells page spot 12;non-selenium glutathione peroxidase;acidic calcium-independent phospholipase A2;epididymis secretory sperm binding protein Li 128m
Recombinant Proteins
- Human
- Mouse
- Bovine
- Rat
- Zebrafish
- Chicken
- Rhesus macaque
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- Mammalian cells
- His
- His&T7
- His&GST
- Non
- GST
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
PRDX6 involved in several pathways and played different roles in them. We selected most pathways PRDX6 participated on our site, such as Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRDX6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | NFS1,CYP4F2,ALOX12B,ADC,ACSL1B,NDUFB1,TPH1,BCO1,CBS,NDUFA7 |
Protein Function
PRDX6 has several biochemical functions, for example, antioxidant activity,glutathione peroxidase activity,peroxiredoxin activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRDX6 itself. We selected most functions PRDX6 had, and list some proteins which have the same functions with PRDX6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| peroxiredoxin activity | PRDX5,PARK7 |
| protein binding | AHR,ACVR1L,SQSTM1,DPEP3,TEC,MRPL15,BNIP3L,ITM2C,MICALL2,FOXL2 |
| phospholipase A2 activity | ABHD3,PLA2G2D,LCAT,PLA2G2E,PLA2G2F,PLA2G6,PLA2G2A,OC90,PLA2G1B,PLA2G12B |
| glutathione peroxidase activity | MGST3,MGST2,GSTZ1,GPX3,GPX5,GPX1B,GPX1A,GPX7,GPX4A,GSTK1 |
| antioxidant activity | SEPW1,APOM,UBIAD1,KDM3B,SELS,MT3,APOA4,FAM213AA,APOE,FABP1 |
| ubiquitin protein ligase binding | RPA3,SUMO2,DAXX,DBT,NLK,FZD5,WASH,CASP10,SKI,CBS |
Interacting Protein
PRDX6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRDX6 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRDX6.
TERF1;YWHAE;1,2-di-o-palmitoyl-sn-glycero-3-phosphocholine;Ncf2;GSTP1;PCNA;ORM2;NR4A1;p29991-pro_0000308465;GPX4;q81xc3_bacan;q8d1c8_yerpe;TERF2IP
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References
- Ding, V; Chin, A; et al. Generation of novel monoclonal antibodies for the enrichment and characterization of human corneal endothelial cells (hCENC) necessary for the treatment of corneal endothelial blindness. MABS 6:1439-1452(2014).
- Akada, J; Kamei, S; et al. A new type of protein chip to detect hepatocellular carcinoma-related autoimmune antibodies in the sera of hepatitis C virus-positive patients. PROTEOME SCIENCE 11:-(2013).
