PRDM2
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Official Full Name
PR domain containing 2, with ZNF domain -
Overview
This tumor suppressor gene is a member of a nuclear histone/protein methyltransferase superfamily. It encodes a zinc finger protein that can bind to retinoblastoma protein, estrogen receptor, and the TPA-responsive element (MTE) of the heme-oxygenase-1 gene. Although the functions of this protein have not been fully characterized, it may (1) play a role in transcriptional regulation during neuronal differentiation and pathogenesis of retinoblastoma, (2) act as a transcriptional activator of the heme-oxygenase-1 gene, and (3) be a specific effector of estrogen action. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008] -
Synonyms
PRDM2;PR domain containing 2, with ZNF domain;RIZ;KMT8;RIZ1;RIZ2;MTB-ZF;HUMHOXY1;PR domain zinc finger protein 2;MTE-binding protein;zinc finger protein RIZ;GATA-3 binding protein G3B;GATA-3-binding protein G3B;lysine N-methyltransferase 8;PR domain-containing protein 2;zinc-finger DNA-binding protein;retinoblastoma protein-binding zinc finger protein;retinoblastoma protein-interacting zinc finger protein
Recombinant Proteins
- Human
- Rat
- Mouse
- E.coli
- Insect Cell
- Mammalian Cell
- HEK293
- HEK293T
- GST
- Non
- His
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PRDM2-3342H | Recombinant Human PRDM2 protein(Met1-Ala200), GST-tagged | E.coli | Human | GST | Met1-Ala200 | |
| PRDM2-3344H | Recombinant Human PRDM2 protein(Met1-Ala200) | E.coli | Human | Non | Met1-Ala200 | |
| PRDM2-172H | Recombinant Human PRDM2 Protein, GST-tagged | Insect Cell | Human | GST | 2-523 |
|
| PRDM2-196H | Recombinant Human PRDM2 protein, GST-tagged | Insect Cell | Human | GST | 1-340 a.a. |
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| PRDM2-27746TH | Recombinant Human PRDM2 | E.coli | Human | Non | 2-200 a.a. |
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| PRDM2-4655R | Recombinant Rat PRDM2 Protein | Mammalian Cell | Rat | His |
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| PRDM2-2911H | Recombinant Human PRDM2 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| PRDM2-4314R | Recombinant Rat PRDM2 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| PRDM2-4314R-B | Recombinant Rat PRDM2 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| Prdm2-475M | Recombinant Mouse Prdm2 Protein, MYC/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| PRDM2-5535H | Recombinant Human PRDM2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
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Involved Pathway
PRDM2 involved in several pathways and played different roles in them. We selected most pathways PRDM2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PRDM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
PRDM2 has several biochemical functions, for example, DNA binding,histone-lysine N-methyltransferase activity,transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRDM2 itself. We selected most functions PRDM2 had, and list some proteins which have the same functions with PRDM2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| zinc ion binding | MLL1,ZZZ3,KDM4A,ADAMTS4,RNF111,GTF2H2C_2,TRIM43C,ADH1B,ING2,RXRAA |
| histone-lysine N-methyltransferase activity | SETD7,SMYD2B,SUV39H1A,SMYD2A,AAAS,EHMT1,EZH2,SMYD3,WHSC1L1,EZH1 |
| transcription factor activity, sequence-specific DNA binding | MYCN,NCOR1,MYC,ZNF75D,SOX21,POU2F2,LHX8A,POU3F2A,TEF,STAT1B |
| DNA binding | FOXG1D,HELT,ASXL3,NR1D4A,POLR3B,PAX1A,TBX5A,ZNF784,ZBTB3,ISL1L |
Interacting Protein
PRDM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRDM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRDM2.
SOD2;q81rm1_bacan;Rpl35
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