PPM1A
-
Official Full Name
protein phosphatase, Mg2+/Mn2+ dependent, 1A -
Overview
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. -
Synonyms
PPM1A;protein phosphatase, Mg2+/Mn2+ dependent, 1A;protein phosphatase 1A (formerly 2C), magnesium dependent, alpha isoform;protein phosphatase 1A;MGC9201;phosphatase 2C alpha;PP2CA;PP2Calpha;protein phosphatase 2C;alpha isoform;protein phosphat
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Mammalian Cells
- HEK293
- His
- GST
- Non
- Avi&Fc&His
- DDK&Myc
Involved Pathway
PPM1A involved in several pathways and played different roles in them. We selected most pathways PPM1A participated on our site, such as MAPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPM1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | MKNK2A,FGF14,CACNA1BA,TGFB1,NLK2,NTRK2,DDIT3,TAOK1,CACNA2D1,NTRK2B |
Protein Function
PPM1A has several biochemical functions, for example, R-SMAD binding,calmodulin-dependent protein phosphatase activity,magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PPM1A itself. We selected most functions PPM1A had, and list some proteins which have the same functions with PPM1A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| manganese ion binding | PPM1NB,GALNT1,GALNT3,LAP3,PEPD,GYLTL1B,IMPA1,SOD2,B4GALT1,PPM1BA |
| magnesium ion binding | RPS6KA1,PGM5,HMGCL,BPNT1,NT5C1A,FOXK2,PKM2,S100P,RPS6KA3A,ADPRH |
| signal transducer activity | MRGPRA8,PRLH2R,MIER1B,CHRM5A,RGRA,MTNR1BB,GPR21,OLFR473,TAS2R121,TICAM1 |
| calmodulin-dependent protein phosphatase activity | PPP3CA,PPP3CB,PPM1F |
| R-SMAD binding | FOXH1,ANKRD1,PAX6,MYOCD,SMAD3,FOS,CTNNB1,TRIM33,PMEPA1,SMAD4 |
| protein C-terminus binding | CITED1,KCNIP3,PHB,ARL6IP5,DDX1,PICK1,NCL,PPP2CA,EFHC1,VGLL1 |
| protein serine/threonine phosphatase activity | CDKN3,PPP5C,PPP2R2A,CTDNEP1B,DUSP23,PPM1DA,PPP6C,DULLARD,PPEF1,PPP2R1A |
| protein binding | GPR85,Itga10&Itgb1,CHIC2,EIF3B,HTR6,ZNF143,EAF2,CELSR1,SPATA7,SMN1 |
Interacting Protein
PPM1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPM1A here. Most of them are supplied by our site. Hope this information will be useful for your research of PPM1A.
MAPK1;RANBP3
Resources
Research Area
Phosphatases and RegulatorsAdherens Junction Proteins in Endothelial Cells
Adherens Junction Proteins in VSMC
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References
