PON1
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Official Full Name
paraoxonase 1 -
Overview
Serum paraoxonase/arylesterase 1 (PON1) also known as aromatic esterase 1 or serum aryldialkylphosphatase 1 is an enzyme that in humans is encoded by the PON1 gene. Paraoxonase 1 has esterase and more specifically paraoxonase activity. PON1 is responsible for hydrolysing organophosphate pesticides and nerve gasses. Polymorphisms in the PON1 gene significantly affect the catalytic ability of the enzyme. PON1 (paraoxonase 1) is also a major anti-atherosclerotic component of high-density lipoprotein (HDL). The PON1 gene is activated by PPAR-γ, which increases synthesis and release of paraoxonase 1 enzyme from the liver, reducing atherosclerosis. -
Synonyms
PON1;ESA;MVCD5;PON;A-esterase 1;K-45;PON 1;aromatic esterase 1;arylesterase B-type;esterase A;paraoxonase B-type;serum aryldiakylphosphatase;serum aryldialkylphosphatase 1;serum paraoxonase/arylesterase 1;paraoxonase 1
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rat
- E.coli
- HEK293
- Trichoplusia Ni Larval
- Mammalian Cell
- HEK293T
- Mammalian cells
- His
- Non
- His&Fc&Avi
- Myc&DDK
- His&GST
- His&Fc
- His&SUMO
- Flag
- GST
Involved Pathway
PON1 involved in several pathways and played different roles in them. We selected most pathways PON1 participated on our site, such as Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PON1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | ACSL4B,DEGS2,PLA2G4D,INPP4B,AANAT1,GLULB,CYP2J6,CS,CYP21A2,PIGB |
Protein Function
PON1 has several biochemical functions, for example, aryldialkylphosphatase activity,arylesterase activity,calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PON1 itself. We selected most functions PON1 had, and list some proteins which have the same functions with PON1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | NR2C1,IKZF2,C1QB,PVRL2L,PVRL1B,UGT1A1,PSMD7,MZF1,SRGAP2,MFF |
| arylesterase activity | C20orf3,CA1,PON3,APMAP,Car2,PON2,CA2,CAR1 |
| phospholipid binding | ANXA1,CPS1,APOA5,BAD,APOH,GLTPD1,STAP1,ANXA9,APOB,APOEA |
| aryldialkylphosphatase activity | PON3 |
| calcium ion binding | GSNB,FKBP9,PKD2,PLCD1A,NDUFAB1,PCDH2AB3,SYTL2,FSTL5,F10,TC2N |
Interacting Protein
PON1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PON1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PON1.
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References
- Shahmohamadnejad, S; Vaisi-Raygani, A; et al. Association between butyrylcholinesterase activity and phenotypes, paraoxonase192 rs662 gene polymorphism and their enzymatic activity with severity of rheumatoid arthritis: Correlation with systemic inflammatory markers and oxidative stress, preliminary report. CLINICAL BIOCHEMISTRY 48:63-69(2015).
- Bednarska-Makaruk, M; Rodo, M; et al. Paraoxonase 1 activity and level of antibodies directed against oxidized low density lipoproteins in a group of an elderly population in Poland - PolSenior study. ARCHIVES OF GERONTOLOGY AND GERIATRICS 60:153-161(2015).
