POLH
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Official Full Name
polymerase (DNA directed), eta -
Overview
This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. [provided by RefSeq, Jul 2008] -
Synonyms
POLH;polymerase (DNA directed), eta;XPV;XP-V;RAD30;RAD30A;DNA polymerase eta;RAD30 homolog A;xeroderma pigmentosum variant type protein
Recombinant Proteins
- Human
- Chicken
- Mouse
- Zebrafish
- E.coli
- Mammalian Cell
- HEK293
- Mammalian cells
- HEK293T
- His
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
POLH involved in several pathways and played different roles in them. We selected most pathways POLH participated on our site, such as Fanconi anemia pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with POLH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fanconi Anemia Pathway | USP1,RMI2,ATRIP,FANCF,BRCA2,RPA1,ERCC4,PALB2,CDK5R2,EME1 |
Protein Function
POLH has several biochemical functions, for example, DNA-directed DNA polymerase activity,damaged DNA binding,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by POLH itself. We selected most functions POLH had, and list some proteins which have the same functions with POLH. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| metal ion binding | ATP1A1B,ZNF839,LMX1BB,NEK7,PDE8B,PHLPP1,TPH1B,ZNF234,ZFP516,BRIP1 |
| damaged DNA binding | POLD1,TP53,CREBBP,TRP63,PNKP,XRCC6,HMGB1,NEIL3,XPA,RAD23A |
| DNA-directed DNA polymerase activity | POLD4,CCDC111,POLD3,POLE3,POLA2,POLG2,PAPD7,POLD2,POLK,POLA1 |
| protein binding | EFEMP2,AES,COL17A1,ITGB3,ATP1B1,ECM1,GAS1,ZNF830,CYSLTR2,TSTD2 |
Interacting Protein
POLH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POLH here. Most of them are supplied by our site. Hope this information will be useful for your research of POLH.
BRCA2;PALB2;UBC;PCNA
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References
- Japp, AS; Gessi, M; et al. High-Resolution Genomic Analysis Does Not Qualify Atypical Plexus Papilloma as a Separate Entity Among Choroid Plexus Tumors. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 74:110-120(2015).
- Nymoen, DA; Holth, A; et al. CIAPIN1 and ABCA13 are markers of poor survival in metastatic ovarian serous carcinoma. MOLECULAR CANCER 14:-(2015).
