PNLIP
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Official Full Name
pancreatic lipase -
Overview
Pancreatic lipase, also known as pancreatic triacylglycerol lipase, is secreted from the pancreas, and is the primary lipase (enzyme) that hydrolyzes (breaks down) dietary fat molecules in the human digestive system, converting triglyceride substrates found in ingested oils to monoglycerides and free fatty acids. Triacylglycerol + H2O diacylglycerol + a fatty acid anion Bile salts secreted from the liver and stored in gallbladder are released into the duodenum where they coat and emulsify large fat droplets into smaller droplets, thus increasing the overall surface area of the fat, which allows the lipase to break apart the fat more effectively. The resulting monomers (2 free fatty acids and one 2-monoacylglycerol) are then moved by way of peristalsis along the small intestine to be absorbed into the lymphatic system by a specialized vessel called a lacteal. This protein belongs to pancreatic lipase family. -
Synonyms
PNLIP;pancreatic lipase;PL;PTL;pancreatic triacylglycerol lipase;OTTHUMP00000020564;triacylglycerol acylhydrolase;Lipase
Recombinant Proteins
- Mouse
- Rat
- Human
- Chicken
- Porcine
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- Human Cell
- Porcine Pancreas
- In Vitro Cell Free System
- HEK293T
- Human Pancreas
- His&SUMO
- His
- Non
- His&T7
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Pnlip-1331M | Recombinant Mouse Pnlip Protein, His-SUMO-tagged | E.coli | Mouse | His&SUMO | 17-465 a.a. |
|
| Pnlip-26R | Recombinant Rat Pnlip protein, His-tagged | E.coli | Rat | His | Ser47~His280 |
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| PNLIP-30776TH | Recombinant Human PNLIP | Wheat Germ | Human | Non | 465 amino acids |
|
| PNLIP-4545R | Recombinant Rat PNLIP Protein | Mammalian Cell | Rat | His |
|
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| PNLIP-4795C | Recombinant Chicken PNLIP | Mammalian Cell | Chicken | His |
|
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| Pnlip-6977M | Recombinant Mouse Pnlip protein, His & T7-tagged | E.coli | Mouse | His&T7 | Gly201~Leu412 |
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| PNLIP-8599H | Recombinant Human PNLIP, His-tagged | HEK293 | Human | His | Met1-Cys465 |
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| PNLIP-1246HCL | Recombinant Human PNLIP cell lysate | Human Cell | Human | Non |
|
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| PNLIP-1175P | Native Porcine Pancreatic Lipase | Porcine Pancreas | Porcine | Non |
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| PNLIP-12H | Human pancreatic lipase from pancreatic juice Reference Standard | Human | Non |
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| PNLIP-13H | Recombinant human pancreatic lipase Reference Standard | Human | Non |
|
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| PNLIP-2415H | Recombinant Human PNLIP Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| PNLIP-2603H | Recombinant Human PNLIP Protein, His-tagged | E.coli | Human | His | Pro245-Cys465 |
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| PNLIP-28H | Recombinant Human PNLIP Protein, N-His Tagged | E.coli | Human | His |
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| PNLIP-375HF | Recombinant Full Length Human PNLIP Protein | In Vitro Cell Free System | Human | Full L. 465 amino acids |
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| PNLIP-4205R | Recombinant Rat PNLIP Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| PNLIP-4205R-B | Recombinant Rat PNLIP Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| Pnlip-4964M | Recombinant Mouse Pnlip Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| PNLIP-8203H | Native Human Pancreatic Lipase | Human Pancreas | Human | Non |
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| PNLIP-8205H | Native Human Pancreas Lipase | Human Pancreas | Human | Non |
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Involved Pathway
PNLIP involved in several pathways and played different roles in them. We selected most pathways PNLIP participated on our site, such as Glycerolipid metabolism,Metabolic pathways,Pancreatic secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with PNLIP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | PCYT1BA,SC5DL,SPS2,ADPGK,XYLT2,GALCA,PIGS,DHDPSL,PIK3C2A,GLUD1B |
| Vitamin digestion and absorption | SLC5A6,CUBN,SLC52A3,LRAT,APOB,SLC19A2,LMBRD1,TCN2,SLC19A1,GIF |
| Pancreatic secretion | KCNQ1,CPB2,RAB3D,CELA2B,TPCN2,PLA2G2A,PRSS1,RAB27B,CCKAR,RAB11A |
| Glycerolipid metabolism | MOGAT1,PPAP2B,AGPAT2,DGKA,CEL.1,DGKAA,AKR1A1,MBOAT2B,CELL,PNLIPRP1 |
| Fat digestion and absorption | CLPS,PNLIPRP1,CD36,PLA2G12B,DGAT2,AGPAT1,SLC27A4,PLA2G12A,PNLIPRP2,PLA2G1B |
Protein Function
PNLIP has several biochemical functions, for example, metal ion binding,triglyceride lipase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PNLIP itself. We selected most functions PNLIP had, and list some proteins which have the same functions with PNLIP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| triglyceride lipase activity | CES3,LPL,Cel,CEL.1,LIPF,PNLIPRP3,PNLIPRP1,CES5A,PNPLA4,PNPLA3 |
| metal ion binding | KLF18,FGD3,AMHR2,TRAF4B,TRIM35-22,ELP3,NEURL1AB,PPM1BB,MYLK,ZNF202 |
Interacting Protein
PNLIP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PNLIP here. Most of them are supplied by our site. Hope this information will be useful for your research of PNLIP.
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References
- Hachero-Cruzado, I; Rodriguez-Rua, A; et al. Characterization of the genomic responses in early Senegalese sole larvae fed diets with different dietary triacylglycerol and total lipids levels. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY D-GENOMICS & PROTEOMICS 12:61-73(2014).
- Behar, DM; Basel-Vanagaite, L; et al. Identification of a novel mutation in the PNLIP gene in two brothers with congenital pancreatic lipase deficiency. JOURNAL OF LIPID RESEARCH 55:307-312(2014).
