PIM3
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Official Full Name
pim-3 oncogene -
Overview
The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is;overexpressed in hematological and epithelial tumors and is associated with MYC coexpression. It plays a role in the;regulation of signal transduction cascades, contributing to both cell proliferation and survival, and provides a;selective advantage in tumorigenesis. -
Synonyms
PIM3;pim-3 oncogene;serine/threonine-protein kinase pim-3;serine/threonine kinase Pim-3;pim-3
Recombinant Proteins
- Mouse
- Human
- Zebrafish
- Rat
- Sf9 Cells
- Sf21 Cells
- Insect Cells
- Mammalian Cells
- E.coli
- HEK293
- GST
- His
- Non
- His&T7
- Myc&DDK
- His&Fc&Avi
Involved Pathway
PIM3 involved in several pathways and played different roles in them. We selected most pathways PIM3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PIM3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
PIM3 has several biochemical functions, for example, ATP binding,protein binding,protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PIM3 itself. We selected most functions PIM3 had, and list some proteins which have the same functions with PIM3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein serine/threonine kinase activity | LMTK3,ARAF,TTN,PLK2,BMPR2A,NLK2,TAOK1,ICK,HIPK4,RPS6KAL |
| protein binding | DDOST,MSH4,C14orf169,TGFBR1,SERPINB8,GINS4,NDRG4,STX8,TRPC3,CRB3 |
| ATP binding | C9orf96,PRPF4BB,RAD51C,PRKACG,OXSR1,KIF3B,GCLC,ATPBD4,SPS2,ACSS2 |
Interacting Protein
PIM3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIM3 here. Most of them are supplied by our site. Hope this information will be useful for your research of PIM3.
MDM2;HSP90AB1
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References
- Lopane, C; Goffredo, V; et al. LPA6 promotes growth and tumorigenicity of hepatocellular carcinoma via activation of PIM-3 proto-oncogene kinase. EUROPEAN JOURNAL OF CANCER 50:161-161(2014).
- Guo, Q; Lan, PX; et al. Immunotherapy for Hepatoma Using a Dual-Function Vector with Both Immunostimulatory and Pim-3-Silencing Effects. MOLECULAR CANCER THERAPEUTICS 13:1503-1513(2014).
