PIM2
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Official Full Name
proviral integration site 2 -
Overview
PIM-2 belongs to a family of cytoplasmic serine/threonine protein kinases that consists of two other members, PIM-1 and PIM-3. Expression of this protein is regulated by hematopoietic cytokines. PIM-2 is most abundantly expressed in hematopoietic tissues, spleen, thymus, and peripheral blood leukocytes, as well as in testis, small intestine, and colon. It is also highly expressed in human leukemic and lymphoma cell lines. The gene is also expressed in primary spermatocytes. The results suggest a role for PIM-2 in proliferating cells as well as during meiosis. PIM-2 is thought to be a mediator of p53 mediated apoptosis inhibition by interleukin 3, which supports its role in the formation of various tumors including lymphomas. -
Synonyms
PIM2;proviral integration site 2;serine/threonine-protein kinase pim-2;Pim-2;DXCch3
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- E.coli
- Sf9 Insect Cell
- Mammalian Cell
- HEK293
- Mammalian cells
- HEK293T
- Insect (sf21)
- GST
- His
- Non
- Flag
- His&T7
- His&Fc&Avi
- Myc&DDK
Involved Pathway
PIM2 involved in several pathways and played different roles in them. We selected most pathways PIM2 participated on our site, such as Acute myeloid leukemia, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Acute myeloid leukemia | KRAS,SFPI1,CEBPA,AKT1,IKBKB,STAT5B,LEF1,CCND1,BAD,PIK3CB |
Protein Function
PIM2 has several biochemical functions, for example, ATP binding,protein binding,protein serine/threonine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PIM2 itself. We selected most functions PIM2 had, and list some proteins which have the same functions with PIM2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein serine/threonine kinase activity | CAMK1DA,CAMKK1A,LMTK2,NLK,MAPK11,STK38A,CSNK1DB,BMPR1B,TSSK4,DCLK3 |
| ATP binding | GLYCTK,MAP3K10,CDC34B,SEPHS1,INSR,ACSM5,ABCB7,STK4,DHX35,UBE2G1A |
| protein binding | HMGN4,VIM,SV2B,AKAP17A,ATP7A,ZFP36L1,C8orf33,SALL4,E4F1,BMP7 |
Interacting Protein
PIM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PIM2.
ZNF821;MDM2;IKBKG;HSP90AB1;q96bx3_human;NDUFB8;HNRNPH3;RPL21;GSK3B;ATXN1;FBXO18;NUP98;PPIL2;CCDC84;PRCC;GPKOW;TOE1;CLK4
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References
- Jiang, YW; Soong, TD; et al. Genome-Wide Detection of Genes Targeted by Non-Ig Somatic Hypermutation in Lymphoma. PLOS ONE 7:-(2012).
- Hallermann, C; Niermann, C; et al. New prognostic relevant factors in primary cutaneous diffuse large B-cell lymphomas. JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY 56:588-597(2007).
