PI4K2A
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Official Full Name
phosphatidylinositol 4-kinase type 2 alpha -
Overview
Phosphatidylinositolpolyphosphates (PtdInsPs) are centrally involved in many biologic processes, ranging from cell;growth and organization of the actin cytoskeleton to endo- and exocytosis. PI4KII phosphorylates PtdIns at the D-4;position, an essential step in the biosynthesis of PtdInsPs (Barylko et al., 2001 (PubMed 11244087)). -
Synonyms
PI4K2A;phosphatidylinositol 4-kinase type 2 alpha;phosphatidylinositol 4-kinase type 2-alpha;DKFZP761G1923;PI4KII;PIK42A;phosphatidylinositol 4-kinase type II-alpha;phosphatidylinositol 4-kinase type II (PI4KII);RP11-548K23.6
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rat
- E.coli
- Sf9 Cells
- Insect Cells
- Mammalian Cells
- HEK293
- His
- GST
- Non
- Avi&Fc&His
- Flag
- DDK&Myc
Involved Pathway
PI4K2A involved in several pathways and played different roles in them. We selected most pathways PI4K2A participated on our site, such as Inositol phosphate metabolism,Metabolic pathways,Phosphatidylinositol signaling system, which may be useful for your reference. Also, other proteins which involved in the same pathway with PI4K2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Inositol phosphate metabolism | PLCD4,INPP5L,PI4KA,PI4K2B,IPMKB,PIK3CD,ITPK1A,SYNJ1,INPPL1A,MTMR6 |
| Phosphatidylinositol signaling system | CALM2B,INPP4A,CALML5,INPP5K,ITPR3,PLCE1,PIP5K1AB,CALM,OCRL,PPIP5K2 |
| Metabolic pathways | LTA4H,FBP2,PPAP2C,SC5DL,GALNT10,AMPD1,AKR1A1A,ATP5IA,POLR2B,GPT2 |
Protein Function
PI4K2A has several biochemical functions, for example, 1-phosphatidylinositol 4-kinase activity,AP-3 adaptor complex binding,ATP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PI4K2A itself. We selected most functions PI4K2A had, and list some proteins which have the same functions with PI4K2A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | CAMK2A,WARS,PDXK,ABCG2A,MARK3,P2RX7,FARS2,FYN,SYN3,STK3 |
| AP-3 adaptor complex binding | RAB32,RAB38 |
| protein binding | BCL2A1A,IL-8,ZBTB49,IKBKE,SPC24,RPS18,CDC42EP2,RPS6KB1,COL18A1,RASA1 |
| magnesium ion binding | ATP10A,CERK,RPS6KA5,GTPBP5,STK38,S100P,TSSK6,HPRT1,MAST4,FARS2 |
| 1-phosphatidylinositol 4-kinase activity | PI4KAB,PI4KA,PI4KAA,PI4K2B,PI4KB |
Interacting Protein
PI4K2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PI4K2A here. Most of them are supplied by our site. Hope this information will be useful for your research of PI4K2A.
ITCH;GABARAP;NOS3;RAD23A;CNOT1;PHF8
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References
- Lemos, T; Verdoorn, KS; et al. Biphasic regulation of type II phosphatidylinositol-4 kinase by sphingosine: Cross talk between glycero- and sphingolipids in the kidney. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES 1838:1003-1009(2014).
- Szentpetery, Z; Szakacs, G; et al. Genetic and functional studies of phosphatidyl-inositol 4-kinase type III alpha. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 1811:476-483(2011).
