PEX14
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Official Full Name
peroxisomal biogenesis factor 14 -
Overview
This gene encodes an essential component of the peroxisomal import machinery. The protein is integrated into peroxisome membranes with its C-terminus exposed to the cytosol, and interacts with the cytosolic receptor for proteins containing a PTS1 peroxisomal targeting signal. The protein also functions as a transcriptional corepressor and interacts with a histone deacetylase. A mutation in this gene results in one form of Zellweger syndrome. -
Synonyms
PEX14;peroxisomal biogenesis factor 14;peroxisomal membrane protein PEX14;NAPP2;NF E2 associated polypeptide 2;Peroxin 14;Peroxin-14;Peroxisomal membrane anchor protein PEX14;PEX14_HUMAN;Pex14p;PTS1 receptor docking protein;PTS1 receptor-docking protein;OTTHUMP00000001902;NF-E2 associated polypeptide 2;peroxisomal membrane anchor protein Pex14p;dJ734G22.2
Recombinant Proteins
- Rat
- Human
- Mouse
- Arabidopsis thaliana
- Dictyostelium Discoideum
- Mammalian Cell
- HEK293
- E.coli
- HEK293T
- E.coli expression system
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
PEX14 involved in several pathways and played different roles in them. We selected most pathways PEX14 participated on our site, such as Peroxisome, which may be useful for your reference. Also, other proteins which involved in the same pathway with PEX14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Peroxisome | ACOX2,PIPOX,HAO2,PAOX,PEX11C,ABCD2,ACAA1,NOS2A,ECI2,DDO |
Protein Function
PEX14 has several biochemical functions, for example, beta-tubulin binding,microtubule binding,protein N-terminus binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PEX14 itself. We selected most functions PEX14 had, and list some proteins which have the same functions with PEX14. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein N-terminus binding | ATM,RPS21,NCOR2,RBPJ,ID1,YWHAQ,GTF2H2,GLRX,PDCD10,MECP2 |
| microtubule binding | SERPINB1A,SPAST,KIAA1128,ARHGEF2,MAPRE2,CNN3,TRAF3IP1,NPSNL,CLIP3,KIF2B |
| receptor binding | FGF6A,LHB,ACOT2,CD200,GSTM7,TGFB2,SERPINE2,FLT3LG,FYNA,FGF6B |
| beta-tubulin binding | ADNP,HDAC6,TRPV4,EMD,GABARAPL2,LRPPRC,SLC6A2,ARL8A,B4GALT1,VAPB |
| transcription corepressor activity | WNT4,CDX2,SIRT1,JUNB,SMARCA4,BASP1,E2F6,HDAC4,SKOR1,SP100 |
| protein binding | POP1,SETMAR,CST2,CALCA,ALKBH6,RAP1GDS1,KCNH7,RHOG,GIMAP7,MAP6 |
Interacting Protein
PEX14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PEX14 here. Most of them are supplied by our site. Hope this information will be useful for your research of PEX14.
PEX19;PEX5
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