PDK4
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Official Full Name
pyruvate dehydrogenase kinase, isozyme 4 -
Overview
This gene is a member of the PDK/BCKDK protein kinase family and encodes a mitochondrial protein with a histidine kinase domain. This protein is located in the matrix of the mitrochondria and inhibits the pyruvate dehydrogenase complex by phosphorylating one of its subunits, thereby contributing to the regulation of glucose metabolism. Expression of this gene is regulated by glucocorticoids, retinoic acid and insulin. [provided by RefSeq, Jul 2008] -
Synonyms
PDK4;pyruvate dehydrogenase kinase, isozyme 4;pyruvate dehydrogenase kinase, isoenzyme 4;pyruvate dehydrogenase, lipoamide, kinase isozyme 4, mitochondrial;[Pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial;[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial
Recombinant Proteins
- Human
- Rat
- Chicken
- Mouse
- Zebrafish
- E.coli
- Wheat Germ
- Mammalian Cell
- Insect Cell
- Insect cells
- HEK293
- In Vitro Cell Free System
- HEK293T
- Mammalian cells
- His
- Non
- His&GST
- His&T7
- GST
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
PDK4 involved in several pathways and played different roles in them. We selected most pathways PDK4 participated on our site, such as Metabolism,Pyruvate metabolism,Pyruvate metabolism and Citric Acid (TCA) cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDK4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pyruvate metabolism and Citric Acid (TCA) cycle | PDK2,ADHFE1,PDK2B,SLC16A1,PDK3B,D2HGDH,MPC1,SLC16A8,PDK3,PDP2 |
| Signal Transduction | PCSK6,NRP2A,RIT2,SOX4A,TAS2R3,FSTL1A,SPRY1,ARHGAP17B,RGS10,CSNK1G2 |
| Pyruvate metabolism | PKMB,DLDH,LDHBA,GLO1,PDP1,PDHA2,PKM2,ACSS2L,SLC16A1,ALDH9A1 |
| Metabolism | MED18,PDP1,PDK3B,MED10,NUBP1,ZDHHC21,CYP2N13,CPOX,ADHFE1,LYRM4 |
| The citric acid (TCA) cycle and respiratory electron transport | C2orf56,ATP5S,LRPPRC,NDUFAF7,BRP44,ADHFE1,SCO1,FAM36A,NDUFAF5,UCP2 |
| Regulation of pyruvate dehydrogenase (PDH) complex | PDPR,PDK2B,PDP2,PDK3B,PDK2,PDP1,PDK3 |
| Signaling by Retinoic Acid | RDH14A,CRABP2,PDK2B,RDH13,RDH10,CRABP2A,FABP11A,RARG,RDH14B,FABP11B |
Protein Function
PDK4 has several biochemical functions, for example, ATP binding,protein kinase activity,pyruvate dehydrogenase (acetyl-transferring) kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PDK4 itself. We selected most functions PDK4 had, and list some proteins which have the same functions with PDK4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| pyruvate dehydrogenase (acetyl-transferring) kinase activity | PDK1,PDK3,PDK2 |
| protein kinase activity | NEK10,TSSK5,RPS6KA3,CSNK2A2A,TGFBR1B,TBCK,CDK1,CSNK1G3,CAMKVB,ARAF |
| ATP binding | EPHB6,DAPK3,SKIV2L2,AKT3A,CARKD,PDIK1L,FRK,MAST2,TTLL10,PTK2BB |
Interacting Protein
PDK4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDK4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PDK4.
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References
- Harada, K; Kakuda, Y; et al. Alteration of energy metabolism in the pathogenesis of bile duct lesions in primary biliary cirrhosis. JOURNAL OF CLINICAL PATHOLOGY 67:396-402(2014).
- Araki, M; Nozaki, Y; et al. Transcriptional regulation of metabolic switching PDK4 gene under various physiological conditions. YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN 127:153-162(2007).
