PDIA2
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Official Full Name
protein disulfide isomerase family A, member 2 -
Overview
Protein disulfide isomerases (EC 5.3.4.1), such as PDIP, are endoplasmic reticulum (ER) resident proteins that catalyze;protein folding and thiol-disulfide interchange reactions (Desilva et al., 1996 (PubMed 8561901)). -
Synonyms
PDIA2;protein disulfide isomerase family A, member 2;PDIP, protein disulfide isomerase, pancreatic , protein disulfide isomerase associated 2;protein disulfide-isomerase A2;PDA2;PDI;PDIR;protein disulfide isomerase A2;Rho GDP dissociation inhibi
Recombinant Proteins
- Mouse
- Zebrafish
- Human
- Rhesus macaque
- E.coli
- Mammalian Cell
- Human
- HEK293
- Yeast
- HEK293T
- Mamanlian cells
- His
- Non
- Myc&DDK
- His&T7
- His&Fc&Avi
- His&SUMO
- Flag
Involved Pathway
PDIA2 involved in several pathways and played different roles in them. We selected most pathways PDIA2 participated on our site, such as Statin Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDIA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Statin Pathway | APOC4,CETP,APOC1 |
Protein Function
PDIA2 has several biochemical functions, for example, disulfide oxidoreductase activity,contributes_to peptidyl-proline 4-dioxygenase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDIA2 itself. We selected most functions PDIA2 had, and list some proteins which have the same functions with PDIA2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | FBXO2,MRAP,DEAF1,NFASC,TOM1,HER5,C22orf23,GHITM,PPFIA2,GNB1 |
| steroid binding | PGR,PAQR7B,HSD11B2,Ar,NR3C1,FAM84B,CYP21A2,PAQR5B,ESR1,ESRRB |
| protein disulfide isomerase activity | GLRX2,PIGK,TXNDC11,PDIA5,PDIA6,QSOX2,QSOX1,ITGB3,TMX4,ZNF169 |
| disulfide oxidoreductase activity | COIL,DNAJC10,PDIA3,TXN,GRX2,TMX1,TXNL1 |
Interacting Protein
PDIA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDIA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PDIA2.
ABL1;FYN;SRC;NCK1;PLCG1;PIK3R1;CRK;GRB2;P4HB;CALR
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References
- Mizuuchi, Y; Aishima, S; et al. Anterior gradient 2 downregulation in a subset of pancreatic ductal adenocarcinoma is a prognostic factor indicative of epithelial-mesenchymal transition. LABORATORY INVESTIGATION 95:193-206(2015).
- Fijak, M; Zeller, T; et al. Autoantibodies against protein disulfide isomerase ER-60 are a diagnostic marker for low-grade testicular inflammation. HUMAN REPRODUCTION 29:2382-2392(2014).
