PDGFC
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Official Full Name
platelet derived growth factor C -
Overview
The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines. This gene product appears to form only homodimers. It differs from the platelet-derived growth factor alpha and beta polypeptides in having an unusual N-terminal domain, the CUB domain. Alternatively spliced transcript variants have been found for this gene. -
Synonyms
PDGFC;platelet derived growth factor C;platelet-derived growth factor C;fallotein;SCDGF;PDGF-C;VEGF-E;spinal cord-derived growth factor;secretory growth factor-like protein;AI647969;1110064L01Rik
Recombinant Proteins
- Mouse
- Human
- Cynomolgus
- Rat
- Chicken
- HEK293
- E.coli
- Mammalian Cells
- Insect Cells
- Human Cells
- Yeast
- Fc
- His
- Non
- T7
- Avi
Involved Pathway
PDGFC involved in several pathways and played different roles in them. We selected most pathways PDGFC participated on our site, such as Ras signaling pathway,Rap signaling pathway,Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDGFC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Melanoma | FGF3,FGF14,FGF16,FGF8,IGF1,FGF12,TP53,FGF18,FGF4,PIK3CB |
| Rap signaling pathway | NGFR,TLN1,INS2,ANGPT1,NGF,RAP1B,RAP1GAP,FYB,PIK3R5,FGF8 |
| Ras signaling pathway | RASAL2,KITLG,SOS1,FGF11,NFKB1,PIK3R5,PLA2G2F,EFNA4,REL,PDGFRB |
| Prostate Cancer | SOS1,MAP2K2,CASP9,CCND1,NFKBIA,ATF4,RAF1,BAD,SRD5A2,PDPK1 |
| Choline metabolism in cancer | CHKA,RAF1,PIK3CB,WASL,GPCPD1,CHKB,MTOR,PRKCA,FOS,PIK3R3 |
| Regulation of Actin Cytoskeleton | WASB,ITGAV,PFN1,DIAP3,FGF6,VAV3,INS,Fgf15,MRAS,ITGB4 |
| Focal adhesion | VCL,CAPN2A,ACTN3B,ITGA1,LAMA5,BAD,ITGB3,PDGFA,THBS4B,TLN2A |
| Gap junction | CX35B,TJP1,TUBB1,HTR2A,PRKACBB,PLCB2,GNAI1,MAP2K2,PRKACAB,GNA11B |
| Phospholipase D signaling pathway | PIK3CA,AKT1,LPAR6,DNM3,F2R,RHEB,TSC2,INS1,PTPN11,ARF6 |
Protein Function
PDGFC has several biochemical functions, for example, growth factor activity,platelet-derived growth factor receptor binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDGFC itself. We selected most functions PDGFC had, and list some proteins which have the same functions with PDGFC. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | BMP7A,PVRL1B,SRM,USF1,RABEP1,BMPR1A,TSC2,CTBP1,BHLHA15,GLIPR2 |
| protein binding | CGGBP1,PRKD2,BMI1,SEC23IP,NAA30,AGXT2L2,RIPK2,MAP2K1,KLHL7,ACTN3 |
| platelet-derived growth factor receptor binding | PDGFB,PTPRJ,PDGFAB,Pdgfa&Pdgfb,ITGB3,ITGA5,PDGFD,FIGF,PDGFA,PDGFRB |
| growth factor activity | GRN,BMP5,FBRS,AMELX,MIA,IL9,EREG,INHBB,CSF1B,LIF |
Interacting Protein
PDGFC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDGFC here. Most of them are supplied by our site. Hope this information will be useful for your research of PDGFC.
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