PDCD6IP
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Official Full Name
programmed cell death 6 interacting protein -
Overview
This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15. [provided by RefSeq, Jan 2012] -
Synonyms
PDCD6IP;programmed cell death 6 interacting protein;AIP1;ALIX;HP95;DRIP4;programmed cell death 6-interacting protein;PDCD6-interacting protein;ALG-2 interacting protein 1;ALG-2-interacting protein X;dopamine receptor interacting protein 4;apoptosis-linked gene 2-interacting protein X
Recombinant Proteins
- Zebrafish
- Human
- Chicken
- Rat
- Mouse
- Mammalian Cell
- E.coli
- HEK293
- E. coli
- Human Cells
- HEK293T
- Mammalian cells
- His
- His&GST
- His&T7
- Non
- N-GST
- His&Fc&Avi
- Myc&DDK
- GST
- Flag
Involved Pathway
PDCD6IP involved in several pathways and played different roles in them. We selected most pathways PDCD6IP participated on our site, such as Budding and maturation of HIV virion,Disease,Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDCD6IP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Late Phase of HIV Life Cycle | NMT2,RCC1,TAF1L |
| Uptake and actions of bacterial toxins | ANTXR1,SYT2,ANTXR2 |
| Budding and maturation of HIV virion | CHMP4C,VPS37A,CHMP4B,gag,PPIA |
| HIV Infection | NMT1,CHMP4C,DOCK2,AP1M2,NMT2,PPIAL4A,AP1S1,PACS1,PSTPIP2,CDK9 |
| Infectious disease | VPS37A,ANTXR2,ANTXR1,CPSF4,CHMP4B,AP1M2,LTF,AP1S1,TAF1L,KPNA5 |
| Disease | CCDC167,RBP4,KERA,RNF43,HEYL,AP1S1,AP1M2,CCR5,MIB1,APOBEC3G |
| HIV Life Cycle | PSIP1,NMT1,TAF1L,TCEB3,ELL,VPS37A,CHMP4B,CHMP4C,RCC1,SSRP1 |
| Endocytosis | SNF8,WWP1,ARR3A,CHMP2B,VPS37A,VPS28,HSP70,GRK6,FMNL3,GRK4 |
Protein Function
PDCD6IP has several biochemical functions, for example, SH3 domain binding,calcium-dependent protein binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDCD6IP itself. We selected most functions PDCD6IP had, and list some proteins which have the same functions with PDCD6IP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium-dependent protein binding | CALM1,NRXN1,PDCD6,S100A1,SLC9A1,S100A4,MASP2,STX1A,MMP13,A2M |
| protein homodimerization activity | PITX2,WRN,AXIN1,DPY30,MAP3K11,RASGRP1,LRRFIP1,ATG7,NUDT16,BCL2A1 |
| protein binding | DEFA6,GSK3B,PPM1K,IRS4,UGGT1,ASCL4,MRPL12,KHDRBS3,DLL4,EWSR1 |
| SH3 domain binding | PTTG1,LANCL1,VASP,HCLS1,PTPN22,FMN1,SH3BP5L,EVL,LYN,EVLB |
| proteinase activated receptor binding | PHB,BICD1 |
Interacting Protein
PDCD6IP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDCD6IP here. Most of them are supplied by our site. Hope this information will be useful for your research of PDCD6IP.
PDCD6;HCK;CEP55;FYN
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References
- Murrow, L; Malhotra, R; et al. ATG12-ATG3 interacts with Alix to promote basal autophagic flux and late endosome function. NATURE CELL BIOLOGY 17:300-+(2015).
- Liu, SG; Yuan, SH; et al. The programmed cell death 6 interacting protein insertion/deletion polymorphism is associated with non-small cell lung cancer risk in a Chinese Han population. TUMOR BIOLOGY 35:8679-8683(2014).
