PAPPA
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Official Full Name
pregnancy-associated plasma protein A, pappalysin 1 -
Overview
This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses. -
Synonyms
PAPPA;pregnancy-associated plasma protein A, pappalysin 1;PAPA;DIPLA1;PAPP-A;PAPPA1;ASBABP2;IGFBP-4ase;pappalysin-1;IGF-dependent IGFBP-4 protease;aspecific BCL2 ARE-binding protein 2;pregnacy-associated plasma protein A;differentially placent
Recombinant Proteins
- Human
- Mouse
- Rat
- HEK293
- Mammalian Cell
- Human Cell
- E.coli
- HEK293T
- Mammalian cells
- His&Avi
- His
- StrepII
- Non
- His&GST
- Myc&DDK
- Flag
- His&Fc&Avi
Involved Pathway
PAPPA involved in several pathways and played different roles in them. We selected most pathways PAPPA participated on our site, such as Metabolism of proteins,Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs), which may be useful for your reference. Also, other proteins which involved in the same pathway with PAPPA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | KLK13,IGFBP1B,IGFBP2A,IGF2B,IGFBP6A,IGFBP5,IGFBP4,IGFBP1A,IGFBP5B,IGFBP6 |
| Metabolism of proteins | IGFBP2,EXOC1,RNF2,CNIH2,ATPBD4,PFDN6,COX17,ADAMTSL1,TBCD,CCT6A |
Protein Function
PAPPA has several biochemical functions, for example, metalloendopeptidase activity,metallopeptidase activity,zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PAPPA itself. We selected most functions PAPPA had, and list some proteins which have the same functions with PAPPA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| zinc ion binding | MARCH2,RFPL2,FBXO40,ZDHHC3,RNF152,ZCWPW1,TRIM30A,RORB,RNF220,LMO7B |
| metalloendopeptidase activity | MMP14,THSD4,MIPEP,ECE1,ADAM5P,MMP19,ADAM18,MMP15,MMP1A,MMP11 |
| metallopeptidase activity | C6AST4,ADAM9,DNPEP,MMP13A,DPP3,CNDP1,BMP1B,XPNPEP2,AGBL4,TMEM27 |
Interacting Protein
PAPPA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAPPA here. Most of them are supplied by our site. Hope this information will be useful for your research of PAPPA.
SMAD9;SKIL;SMAD3;SMAD2;ATF7IP;IGHG1;IGHM
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