NR5A2

  • Official Full Name

    NR5A2 nuclear receptor subfamily 5, group A, member 2

  • Overview

    Liver receptor homolog-1 (LRH-1), also known as NR5A2, is a member of the orphan nuclear receptor family. It has been linked to a variety of processes, such as bile acid metabolism, reverse cholesterol transport, cell proliferation in the developing pancreas, and steroidogenesis.

  • Synonyms

    NR5A2;nuclear receptor subfamily 5, group A, member 2;FTF;nuclear receptor subfamily 5 group A member 2;B1F2;FTZ F1;FTZ F1beta;hB1F;hB1F 2;liver receptor homolog 1;LRH 1;nuclear receptor NR5A2;liver receptor homolog-1;CYP7A promoter-binding factor;hepatocytic transcription factor;alpha-1-fetoprotein transcription factor;liver nuclear receptor homolog-1 variant 2;fetoprotein-alpha 1 (AFP) transcription factor;b1-binding factor, hepatocyte transcription factor which activates enhancer II of hepatitis B virus;B1F;CPF;LRH1;LRH-1;FTZ-F1;hB1F-2;FTZ-F1beta

Recombinant Proteins

  • Human
  • Rat
  • Chicken
  • Zebrafish
  • Mouse
  • Insect Cell
  • E.coli
  • Mammalian Cell
  • E. coli
  • HEK293
  • Wheat Germ
  • In Vitro Cell Free System
  • Non
  • GST
  • His
  • His&T7
  • His&Myc
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
NR5A2-1052H Recombinant Human NR5A2 Insect Cell Human Non
NR5A2-1053H Recombinant Human NR5A2, GST-tagged E.coli Human GST
NR5A2-1092H Recombinant Human NR5A2 protein, His-tagged E.coli Human His Ser300~Ala541
Nr5a2-1093R Recombinant Rat Nr5a2 protein, His & T7-tagged E.coli Rat His&T7 Met1~Ala205
NR5A2-2505H Recombinant Human NR5A2, His-tagged Insect Cell Human His
NR5A2-4074R Recombinant Rat NR5A2 Protein Mammalian Cell Rat His
NR5A2-6635C Recombinant Chicken NR5A2 Mammalian Cell Chicken His
NR5A2-9030Z Recombinant Zebrafish NR5A2 Mammalian Cell Zebrafish His
NR5A2-004H Recombinant Human nuclear receptor subfamily 5 group A member 2 Protein, His tagged E. coli Human His 1-303 aa
Nr5a2-3292M Recombinant Mouse Nr5a2 protein, His&Myc-tagged E.coli Mouse His&Myc 1-560aa
NR5A2-3733R Recombinant Rat NR5A2 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
NR5A2-3733R-B Recombinant Rat NR5A2 Protein Pre-coupled Magnetic Beads HEK293 Rat
NR5A2-6100H Recombinant Human NR5A2 Protein, GST-tagged Wheat Germ Human GST
NR5A2-6747HF Recombinant Full Length Human NR5A2 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 495 amino acids

    Involved Pathway

    NR5A2 involved in several pathways and played different roles in them. We selected most pathways NR5A2 participated on our site, such as Maturity onset diabetes of the young, which may be useful for your reference. Also, other proteins which involved in the same pathway with NR5A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Maturity onset diabetes of the young FOXA2,HES1,SLC2A2,INS1,NKX6,HNF4G,HHEX,NKX6-1,PDX1,HNF1B

    Protein Function

    NR5A2 has several biochemical functions, for example, DNA binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,RNA polymerase II distal enhancer sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NR5A2 itself. We selected most functions NR5A2 had, and list some proteins which have the same functions with NR5A2. You can find most of the proteins on our site.

    Function Related Protein
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding SOX9,EGR2,MTF1,CRX,ZFP639,BSX,TFE3,SMAD1,ESRRA,CAMTA2
    steroid hormone receptor activity PAQR7A,VDRA,NR2F1A,RORC,NR6A1A,VDRB,RORCA,RARAB,ESRRB,NR4A2
    RNA polymerase II distal enhancer sequence-specific DNA binding SOX10,TAL1,PBX3,ESRRB,HNRNPC,ARID3B,MIXL1,NR2F6,T,PAX4
    transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding FOXP3,MYOG,NFIX,CIR1,SOX7,PDX1,SOX17,TLE4,MYOD1,GTF2IRD1
    transcription regulatory region sequence-specific DNA binding HDAC1,NR5A5,HIF1AL,BAHD1,POU2F1,KDM3A,FOXN1,SIN3A,CREB3L3,GATA1
    RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding VDRA,AHR,ESRRA,HNF4A,NR1I2,PPARG,RORB,NR2F6,PTGER3,NR1H3
    RNA polymerase II core promoter proximal region sequence-specific DNA binding RFX6,HOXA7,CEBPA,TCF12,HHEX,PITX1,ELF4,CUX2,MYBL1,NR4A3
    transcription regulatory region DNA binding SALL3,Ar,ARID4A,ZFP821,GRHL1,WNT5A,CTCF,PAX8,ZNF217,ZNF567
    transcription factor activity, sequence-specific DNA binding DMRTA2,MYCL1,TCF7L1A,ZNF490,SOX11A,GLI3,POU3F4,HOXC8,NFIL3,THRAA

    Interacting Protein

    NR5A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NR5A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NR5A2.

    UBE2I;EDF1;PROX1

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